Chemoprevention drug development has the goal of identifying safe and effective
chemopreventive agents for clinical use. Several distinctive strategies are pursued in …

Clinical chemoprevention trials of more than 30 agents and agent combinations are now in
progress or being planned. The most advanced agents are well known and are in large …

Publisher Summary This chapter focuses on the nature of carcinogenesis and provides an
overview of the progress in this field, and presents successful strategies in …

A search of the literature using National Library of Medicine databases and individual
cancer journal articles yielded over 500 compounds with published chemopreventive activity …

Strategies for chemopreventative drug development are based on the use of well-
characterized agents, intermediate biomarkers correlating to cancer incidence, and suitable …

This is the second publication of Clinical Development Plans from the National Cancer
Institute, Division of Cancer Prevention and Control, Chemoprevention Branch and Agent …

Chemoprevention is an innovative area of cancer research that focuses on the development
of pharmacological, biological, and nutritional interventions to prevent, reverse, or delay …

More than 40 promising agents and agent combinations are being evaluated clinically as
chemopreventive drugs for major cancer targets. A few have been in vanguard, large‐scale …

Chemoprevention is the use of natural or synthetic compounds to block, reverse, or prevent
the development of invasive cancers. Cellular carcinogenesis forms the biologic basis for …

In the late 20th century, the treatment of cancer began to include its prevention. Today,
compounds exist that will lower the risk of developing certain types of cancer. This has been …