Aims Deprescribing is a suggested intervention to reverse the potential iatrogenic harms of
inappropriate polypharmacy. The review aimed to determine whether or not deprescribing is …

Background Mixed findings about deprescribing impact have emerged from varied study
designs, interventions, outcome measures and targeting sub-categories of medications or …

Older people with chronic disease have great potential to benefit from their medications but
are also at high risk of harm from their medications. The use of medications is particularly …

Polypharmacy is a major challenge in healthcare for older people, and is associated with
increased risks of adverse outcomes, such as delirium, falls, frailty, cognitive impairment and …

Polypharmacy is common in older adults and associated with inappropriate medication use,
adverse drug events, medication nonadherence, higher costs, and increased mortality …

Background Polypharmacy and potentially inappropriate medications (PIMs) are prevalent
in older adults in hospital, and are associated with negative outcomes including adverse …

Background Older people living with frailty are often exposed to polypharmacy and potential
harm from medications. Targeted deprescribing in this population represents an important …

Introduction: As with prescribing or continuing medications, deprescribing brings with it the
potential for harm as well as benefit. Uncertainty and avoidance of harm has been reported …

Deprescribing has gained interest recently, driven by an ageing population seeing an
increasing number living with multiple long-term conditions. This, coupled with disease …

1370 CMAJ, December 9, 2014, 186 (18) ognition that careful adherence to disease-specific
guidelines in frail patients can result in increased risks of drug interactions and adverse …