The effect of a 2-h exposure to cigarette smoke on the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in A/J …
BG Brown, E Richter, AR Tricker, PH Ayres… - Chemico-biological …, 2001 - Elsevier
4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine,
induces lung adenomas in A/J mice following a single intraperitoneal (ip) injection …
induces lung adenomas in A/J mice following a single intraperitoneal (ip) injection …
The effect of cotinine or cigarette smoke co-administration on the formation of O6-methylguanine adducts in the lung and liver of A/J mice treated with 4 …
BG Brown, CJ Chang, PH Ayres, CK Lee… - … sciences: an official …, 1999 - academic.oup.com
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific nitrosamine,
induces lung adenomas in A/J mice, following a single intraperitoneal (ip) injection …
induces lung adenomas in A/J mice, following a single intraperitoneal (ip) injection …
Biotransformation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in lung tissue from mouse, rat, hamster, and man
E Richter, J Engl, S Friesenegger… - Chemical research in …, 2009 - ACS Publications
Exposure to the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) is considered to be an important etiological risk factor for lung cancer in …
butanone (NNK) is considered to be an important etiological risk factor for lung cancer in …
Effect of nicotine, cotinine and phenethyl isothiocyanate on 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) metabolism in the Syrian golden hamster
E Richter, AR Tricker - Toxicology, 2002 - Elsevier
The effect of nicotine, cotinine and phenethyl isothiocyanate (PEITC) on metabolism of the
tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was …
tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) was …
Nicotine inhibits the metabolic activation of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats
E Richter, AR Tricker - Carcinogenesis, 1994 - academic.oup.com
The effect of nicotine on the metabolism of the tobacco-specific nitrosamine 4-
(methylnitrosamlno)-1-(3-pyridyl)-1-butanone (NNK) was studied in rats.[1-14C] NNK was sc …
(methylnitrosamlno)-1-(3-pyridyl)-1-butanone (NNK) was studied in rats.[1-14C] NNK was sc …
Coexposure to inhaled aldehydes or carbon dioxide enhances the carcinogenic properties of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1 …
LA Peterson, MK Oram, M Flavin… - Chemical research in …, 2021 - ACS Publications
Tobacco smoke is a complex mixture of chemicals, many of which are toxic and
carcinogenic. Hazard assessments of tobacco smoke exposure have predominantly focused …
carcinogenic. Hazard assessments of tobacco smoke exposure have predominantly focused …
Stereoselective Metabolism of Nicotine and Tobacco-Specific N-Nitrosamines to 4-Hydroxy-4-(3-pyridyl)butanoic Acid in Rats
N Trushin, SS Hecht - Chemical research in toxicology, 1999 - ACS Publications
The carcinogenic tobacco-specific nitrosamines 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) and N '-nitrosonornicotine (NNN) are believed to play a role in cancers …
butanone (NNK) and N '-nitrosonornicotine (NNN) are believed to play a role in cancers …
The profile of urinary metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in rats is determined by its pulmonary metabolism
T Schneider, E Frei, M Wiessler - Chemico-biological interactions, 1999 - Elsevier
Metabolism of the tobacco specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-
butanone (NNK) in rats was compared to metabolism in primary lung and liver cells …
butanone (NNK) in rats was compared to metabolism in primary lung and liver cells …
Metabolism of 4-(Methylnitrosamino)-1-(3-Pyridyl)-1-Butanone (Nnk) in A/J Mouse Lung And Effect of Cigarette Smoke Exposure on in Vivo Metabolism to Biological …
AR Tricker, BG Brown, DJ Doolittle… - … Reactive Intermediates VI …, 2001 - Springer
It has been proposed that the tobacco-specific N-nitrosamine 4-(methylnitrosamino)-1-(3-
pyridyl)-1-butanone (NNK) may be involved in the causation of human lung cancer (Hecht …
pyridyl)-1-butanone (NNK) may be involved in the causation of human lung cancer (Hecht …
Recent studies on mechanisms of bioactivation and detoxification of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific lung carcinogen
SS Hecht - Tobacco-Specific N-Nitrosamines Recent …, 2017 - api.taylorfrancis.com
This article reviews recent advances in the biochemistry and molecular biology of 4-
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific pulmonary car …
(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK), a tobacco-specific pulmonary car …