Abstract β-catenin is widely regarded as the primary transducer of canonical WNT signals to
the nucleus. In most vertebrates, there are eight additional catenins that are structurally …

Members of the catenin family were first isolated complexed with the cytoplasmic domains of
cadherins at cell-cell junctions, and this relationship is considered one of the defining …

Vertebrate beta-catenin plays a key role as a transducer of canonical-Wnt signals. We
earlier reported that, similar to beta-catenin, the cytoplasmic signaling pool of p120-catenin …

Wnt signaling pathways have fundamental roles in animal development and tumor
progression. Here, employing Xenopus embryos and mammalian cell lines, we report that …

For more than a decade, cell, developmental and cancer investigators have brought about a
wide interest in the biology of catenin proteins, an attraction being their varied functions …

The prevailing view of canonical Wnt signaling emphasizes the role of beta-catenin acting
downstream of Wnt activation to regulate transcriptional activity. However, emerging …

β-Catenin, apart from playing a cell-adhesive role, is a key nuclear effector of Wnt signaling.
Based on activity assays in Drosophila, we generated mouse strains where the endogenous …

β-Catenin plays essential roles in both cell–cell adhesion and Wnt signal transduction, but
what precisely controls β-catenin targeting to cadherin adhesive complexes, or T-cell factor …

After two decades of stardom, one would think that β‐catenin has revealed all of its most
intimate details. Yet the essence of its duality has remained mysterious—how can a single …

Modulators of cadherin function are of great interest given that the cadherin complex actively
contributes to the morphogenesis of virtually all tissues. The catenin p120ctn (formerly …