Pathogenesis, symptomatology, and transmission of SARS-CoV-2 through analysis of viral genomics and structure

HM Rando, AL MacLean, AJ Lee, R Lordan, S Ray… - …, 2021 - Am Soc Microbiol
The novel coronavirus SARS-CoV-2, which emerged in late 2019, has since spread around
the world and infected hundreds of millions of people with coronavirus disease 2019 …

Structural genomics of SARS-CoV-2 indicates evolutionary conserved functional regions of viral proteins

S Srinivasan, H Cui, Z Gao, M Liu, S Lu, W Mkandawire… - Viruses, 2020 - mdpi.com
During its first two and a half months, the recently emerged 2019 novel coronavirus, SARS-
CoV-2, has already infected over one-hundred thousand people worldwide and has taken …

Immuno-epidemiology and pathophysiology of coronavirus disease 2019 (COVID-19)

OA Olwenyi, SR Dyavar, A Acharya, AT Podany… - Journal of Molecular …, 2020 - Springer
Occasional zoonotic viral attacks on immunologically naive populations result in massive
death tolls that are capable of threatening human survival. Currently, severe acute …

Genomic determinants of pathogenicity in SARS-CoV-2 and other human coronaviruses

AB Gussow, N Auslander, G Faure… - Proceedings of the …, 2020 - National Acad Sciences
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) poses an immediate, major
threat to public health across the globe. Here we report an in-depth molecular analysis to …

Genomic and evolutionary comparison between SARS-CoV-2 and other human coronaviruses

Z Chen, SS Boon, MH Wang, RWY Chan… - Journal of virological …, 2021 - Elsevier
Three highly pathogenic human coronaviruses can cause severe acute respiratory
syndrome (SARS-CoV, SARS-CoV-2 and MERS-CoV). Although phylogenetic analyses …

Interactomes of SARS‐CoV‐2 and human coronaviruses reveal host factors potentially affecting pathogenesis

Z Chen, C Wang, X Feng, L Nie, M Tang… - The EMBO …, 2021 - embopress.org
Host–virus protein–protein interactions play key roles in the life cycle of severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2). We conducted a comprehensive …

Genome-wide bioinformatic analyses predict key host and viral factors in SARS-CoV-2 pathogenesis

MG Ferrarini, A Lal, R Rebollo, AJ Gruber… - Communications …, 2021 - nature.com
The novel betacoronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
caused a worldwide pandemic (COVID-19) after emerging in Wuhan, China. Here we …

SARS-CoV-2: phylogenetic origins, pathogenesis, modes of transmission, and the potential role of nanotechnology

AK Sahu, M Sreepadmanabh, M Rai, A Chande - Virusdisease, 2021 - Springer
The COVID-19 pandemic has elicited a rapid response from the scientific community with
significant advances in understanding the causative pathogen (SARS-CoV-2). Mechanisms …

From SARS to SARS-CoV-2, insights on structure, pathogenicity and immunity aspects of pandemic human coronaviruses

N Kirtipal, S Bharadwaj, SG Kang - Infection, Genetics and Evolution, 2020 - Elsevier
Abstract Human Coronaviruses (HCoV), periodically emerging across the world, are
potential threat to humans such as severe acute respiratory syndrome coronavirus-2 (SARS …

Morphology, genome organization, replication, and pathogenesis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)

S Kumar, R Nyodu, VK Maurya, SK Saxena - Coronavirus Disease 2019 …, 2020 - Springer
SARS-CoV-2 is a single-stranded RNA virus of~ 30 kb genome size which belongs to genus
Coronavirus and family Coronaviridae. SARS-CoV-2 has recently emerged and has been …