For all organisms promoting protein homeostasis is a high priority in order to optimize
cellular functions and resources. However, there is accumulating evidence that aging leads …

Damaged and misfolded proteins accumulate during the aging process, impairing cell
function and tissue homeostasis. These perturbations to protein homeostasis (proteostasis) …

Cells possess an extensive network of components to safeguard proteome integrity and
maintain protein homeostasis (proteostasis). When this proteostasis network (PN) declines …

Proteome maintenance is crucial to cellular health and viability, and is typically thought to be
controlled in a cell-autonomous manner. However, recent evidence indicates that protein …

Cells invest in an extensive network of factors to maintain protein homeostasis (proteostasis)
and prevent the accumulation of potentially toxic protein aggregates. This proteostasis …

The functional health of the proteome is determined by properties of the proteostasis
network (PN) that regulates protein synthesis, folding, macromolecular assembly …

Protein turnover is an effective way of maintaining a functional proteome, as old and
potentially damaged polypeptides are destroyed and replaced by newly synthesized copies …

Protein homeostasis or proteostasis is an essential balance of cellular protein levels
mediated through an extensive network of biochemical pathways that regulate different …

The long-term health of the cell is inextricably linked to protein quality control. Under optimal
conditions this is accomplished by protein homeostasis, a highly complex network of …

The proteostasis network (PN) regulates protein synthesis, folding, transport, and
degradation to maintain proteome integrity and limit the accumulation of protein aggregates …