Therapeutic effects of gentiopicroside on adjuvant-induced arthritis by inhibiting inflammation and oxidative stress in rats

X Xie, H Li, Y Wang, Z Wan, S Luo, Z Zhao, J Liu… - International …, 2019 - Elsevier
The purpose of this research was to evaluate the therapeutic effects of gentiopicroside
(GPS) on adjuvant-induced arthritis (AA) rats. Rats were injected with complete Freund's …

Gentiopicroside attenuates collagen-induced arthritis in mice via modulating the CD147/p38/NF-κB pathway

N Jia, H Ma, T Zhang, L Wang, J Cui, Y Zha… - International …, 2022 - Elsevier
Gentiopicroside (GEN) is a secoiridoid glycosides isolated from a traditional Chinese
medicine Gentiana macrophylla Pall.. It exhibits potential activities in the treatment of …

Anti-rheumatic properties of gentiopicroside are associated with suppression of ROS-NF-κB-NLRP3 axis in fibroblast-like synoviocytes and NF-κB pathway in adjuvant …

M Wang, H Li, Y Wang, Y Hao, Y Huang… - Frontiers in …, 2020 - frontiersin.org
Rheumatoid arthritis (RA) is among the most prevalent forms of autoimmunity.
Gentiopicroside (Gent) is an iridoid glucoside derived from the Gentiana Macrophylla Pall …

Effects and mechanisms of Geniposide on rats with adjuvant arthritis

MM Dai, H Wu, H Li, J Chen, JY Chen, SL Hu… - International …, 2014 - Elsevier
Geniposide (GE), an iridoid glycoside compound, is the major active ingredient of Gardenia
jasminoides Ellis (GJ) fruit which has anti-inflammatory and other important therapeutic …

Ginsenoside metabolite compound K attenuates inflammatory responses of adjuvant-induced arthritis rats

H Wu, J Chen, Q Wang, X Jia, S Song… - …, 2014 - Taylor & Francis
Objective: To investigate the effects of ginsenoside metabolite compound K (CK) on
adjuvant-induced arthritis (AA) rats and the partial mechanisms focused on the function of …

Anti-inflammatory effects and pharmacokinetics study of geniposide on rats with adjuvant arthritis

JY Chen, H Wu, H Li, SL Hu, M Dai, J Chen - International …, 2015 - Elsevier
The aim of this study was to explore the anti-inflammatory effects of Geniposide (GE), an
iridoid glycoside compound extracted from Gardenia jasminoides Ellis (GJ) fruit in adjuvant …

Protective effect of gentianine, a compound from Du Huo Ji Sheng Tang, against freund's complete adjuvant-induced arthritis in rats

C Wenjin, W Jianwei - Inflammation, 2017 - Springer
The anti-inflammatory property of gentianine (GE) aroused our interest. To investigate the
effect of GE on Freund's complete adjuvant (FCA)-induced arthritis in rats was the aim of this …

Gentiopicroside prevents interleukin-1 beta induced inflammation response in rat articular chondrocyte

L Zhao, J Ye, G Wu, X Peng, P Xia, Y Ren - Journal of Ethnopharmacology, 2015 - Elsevier
Abstract Ethnopharmacological relevance In traditional Chinese medicine, Gentiana
macrophylla Pall have been prescribed for the treatment of pain and inflammatory …

Combination therapy of ginsenoside compound K and methotrexate was efficient in elimination of anaemia and reduction of disease activity in adjuvant-induced …

J Chen, W Wang, M Jiang, M Yang… - Pharmaceutical Biology, 2020 - Taylor & Francis
Abstract Context Ginsenoside compound K (CK) has anti-inflammatory, immunoregulatory,
and myelosuppressive protective effects. Methotrexate (MTX) is widely used in combination …

Stigmasterol protects rats from collagen induced arthritis by inhibiting proinflammatory cytokines

MA Khan, AHMG Sarwar, R Rahat, RS Ahmed… - International …, 2020 - Elsevier
Rheumatoid arthritis (RA) is an autoimmune disorder, in which imbalance in synthesis and
production of inflammatory cytokines promotes cartilage and bone destruction. Out of the …