Puerarin protects brain tissue against cerebral ischemia/reperfusion injury by inhibiting the inflammatory response

F Zhou, L Wang, P Liu, W Hu, X Zhu… - Neural Regeneration …, 2014 - journals.lww.com
Puerarin, a traditional Chinese medicine, exerts a powerful neuroprotective effect in cerebral
ischemia/reperfusion injury, but its mechanism is unknown. Here, we established rat models …

Puerarin partly counteracts the inflammatory response after cerebral ischemia/reperfusion via activating the cholinergic anti-inflammatory pathway

X Liu, Z Mei, J Qian, Y Zeng… - Neural regeneration …, 2013 - journals.lww.com
Puerarin, a major isoflavonoid derived from the Chinese medical herb radix puerariae
(Gegen), has been reported to inhibit neuronal apoptosis and play an anti-inflammatory role …

Puerarin protects against ischemic brain injury in a rat model of transient focal ischemia

L Gao, X Ji, J Song, P Liu, F Yan, W Gong… - Neurological …, 2009 - Taylor & Francis
Objectives: This study examines the efficacy of puerarin, a drug used in traditional Chinese
medicine, in attenuating ischemic brain injury after cerebral ischemia and reperfusion, and …

Puerarin protects rat brain against ischemia/reperfusion injury by suppressing autophagy via the AMPK-mTOR-ULK1 signaling pathway

JF Wang, ZG Mei, Y Fu, SB Yang… - Neural regeneration …, 2018 - journals.lww.com
Puerarin suppresses autophagy to alleviate cerebral ischemia/reperfusion injury, and
accumulating evidence indicates that the AMPK-mTOR signaling pathway regulates the …

Neuroprotective mechanisms of puerarin in middle cerebral artery occlusion-induced brain infarction in rats

Y Chang, CY Hsieh, ZA Peng, TL Yen, G Hsiao… - Journal of Biomedical …, 2009 - Springer
Puerarin, a major isoflavonoid derived from the Chinese medical herb Radix puerariae
(kudzu root), has been reported to be useful in the treatment of various cardiovascular …

Protective effect of puerarin on acute cerebral ischemia in rats

L Wang, A Zhao, F Wang, Q Chai… - Zhongguo Zhong yao za …, 1997 - europepmc.org
Acute incomplete brain ischemia in rats was induced by bilateral carotid artery occlusion
(BCAO). BCAO results in severe suppression of EEG and increase of brain water content …

Puerarin protected the brain from cerebral ischemia injury via astrocyte apoptosis inhibition

N Wang, Y Zhang, L Wu, Y Wang, Y Cao, L He, X Li… - …, 2014 - Elsevier
Puerarin is extensively attractive because of its superior neuroprotective effects in stroke
prevention. This paper focused on the protective effect of puerarin both in vivo and in vitro …

Puerarin: A protective drug against ischemia-reperfusion injury

M Gao, Z Zhang, K Lai, Y Deng, C Zhao, Z Lu… - Frontiers in …, 2022 - frontiersin.org
Ischemia-reperfusion (I/R) is a pathological process that occurs in numerous organs
throughout the human body and is frequently associated with severe cellular damage and …

Puerarin inhibited oxidative stress and alleviated cerebral ischemia-reperfusion injury through PI3K/Akt/Nrf2 signaling pathway

Q Zhang, M Yao, J Qi, R Song, L Wang, J Li… - Frontiers in …, 2023 - frontiersin.org
Introduction: Puerarin (PUE) is a natural compound isolated from Puerariae Lobatae Radix,
which has a neuroprotective effect on IS. We explored the therapeutic effect and underlying …

Protective effects and mechanism of puerarin on learning-memory disorder after global cerebral ischemia-reperfusion injury in rats

H Wu, H Guo, H Wang, M Chang, G Zhang… - Chinese journal of …, 2009 - Springer
Objective To observe the effect of puerarin on the learning-memory disorder after global
cerebral ischemia-reperfusion injury in rats, and to explore its mechanism of action. Methods …