The elevated susceptibility to diabetes in India: an evolutionary perspective

JCK Wells, E Pomeroy, SR Walimbe… - Frontiers in public …, 2016 - frontiersin.org
India has rapidly become a “diabetes capital” of the world, despite maintaining high rates of
under-nutrition. Indians develop diabetes at younger age and at lower body weights than …

Type 2 diabetes: why we are winning the battle but losing the war? 2015 Kelly West Award Lecture

KMV Narayan - Diabetes care, 2016 - Am Diabetes Assoc
Diabetes is among the biggest of the 21st-century global health challenges. In the US and
other high-income countries, thanks to investments in science, dedication to implementing …

The diabesity epidemic in the light of evolution: insights from the capacity–load model

JCK Wells - Diabetologia, 2019 - Springer
The global nutrition transition, which embraces major changes in how food is produced,
distributed and consumed, is associated with rapid increases in the prevalence of obesity …

Low risk threshold for acquired diabetogenic factors in Asian Indians

A Ramachandran, C Snehalatha, V Vijay - Diabetes research and clinical …, 2004 - Elsevier
India is facing an epidemic of type 2 diabetes, with high prevalence in urban areas.
Urbanisation and associated life style changes adversely affect the risk factors for diabetes …

Body composition and susceptibility to type 2 diabetes: an evolutionary perspective

JCK Wells - European Journal of Clinical Nutrition, 2017 - nature.com
Type 2 diabetes is rapidly increasing in prevalence worldwide, in concert with epidemics of
obesity and sedentary behavior that are themselves tracking economic development. Within …

Pathophysiology, phenotypes and management of type 2 diabetes mellitus in Indian and Chinese populations

C Ke, KMV Narayan, JCN Chan, P Jha… - Nature Reviews …, 2022 - nature.com
Nearly half of all adults with type 2 diabetes mellitus (T2DM) live in India and China. These
populations have an underlying predisposition to deficient insulin secretion, which has a key …

Type 2 diabetes in India: regional disparities

R Gupta, A Misra - The British Journal of Diabetes & …, 2007 - journals.sagepub.com
Type 2 diabetes mellitus epidemic in India is a result of societal influences and changing
lifestyles. Diabetes has been known in India for centuries as a disease of the affluent class …

Tale of two Indians: heterogeneity in type 2 diabetes pathophysiology

LR Staimez, M Deepa, MK Ali, V Mohan… - Diabetes/metabolism …, 2019 - Wiley Online Library
Aims Type 2 diabetes is a heterogeneous disease and may manifest from multiple disease
pathways. We examined insulin secretion and insulin resistance across two ethnicities with …

Globalization of diabetes: the role of diet, lifestyle, and genes

FB Hu - Diabetes care, 2011 - Am Diabetes Assoc
Type 2 diabetes is a global public health crisis that threatens the economies of all nations,
particularly developing countries. Fueled by rapid urbanization, nutrition transition, and …

Incidence and pathophysiology of diabetes in South Asian adults living in India and Pakistan compared with US blacks and whites

KMV Narayan, D Kondal, N Daya, UP Gujral… - BMJ Open Diabetes …, 2021 - drc.bmj.com
Introduction We compared diabetes incidence in South Asians aged≥ 45 years in urban
India (Chennai and Delhi) and Pakistan (Karachi), two low-income and middle-income …