Sickle cell anaemia is associated with a mutant haemoglobin, HbS, which forms polymers in
the red blood cells of patients. The primary role of the HbS polymerization for the …

In search of novel control parameters for the polymerization of sickle cell hemoglobin (HbS),
the primary pathogenic event of sickle cell anemia, we explore the role of free heme, which …

Sickle cell anemia is a debilitating genetic disease that affects hundreds of thousands of
babies born each year worldwide. Its primary pathogenic event is the polymerization of a …

The primary pathogenic event of sickle cell anemia is the polymerization of the mutant
hemoglobin (Hb) S within the red blood cells, occurring when HbS is in deoxy state in the …

Pathogenesis in sickle cell disease depends on polymerization and gelation of
deoxyhemoglobin S. Under the double nucleation model, polymerization is initiated by …

In the last few years, the understanding of the molecular basis of sickle cell disease has
progressed rapidly. It is now possible to describe the structure of the gel of polymerized …

Polymerization of sickle cell hemoglobin (HbS) in deoxy state is one of the basic events in
the pathophysiology of sickle cell anemia. For insight into the polymerization process, we …

Recent work has enabled us to quantitate the four variables (2, 3-DPG concentration, pHi,
non-S hemoglobin composition, and O2 saturation) that modulate the equilibrium solubility …

Abstract 70 years ago, Linus Pauling, the legendary genius of 20th century chemistry,
published his famous work on the molecular cause of sickle cell disease, a paper that gave …

Sickle cell disease (SCD) is characterized by the presence of sickle hemoglobin (HbS),
which has the unique property of polymerizing when deoxygenated. The sickling process is …