Abstract Dopamine D 2 receptor (D 2 R) activation triggers both G protein-and β-arrestin-
dependent signaling. Biased D 2 R ligands activating β-arrestin pathway have been …

The existence of A 2A-D 2 heteromeric complexes is based on coimmunoprecipitation
studies and on fluorescence resonance energy transfer and bioluminescence resonance …

Dopamine and adenosine receptors are known to share a considerable overlap in their
regional distribution, being especially rich in the basal ganglia. Dopamine and adenosine …

Recently evidence has been presented that adenosine A2A and dopamine D2 receptors
form functional heteromeric receptor complexes as demonstrated in human neuroblastoma …

Forebrain dopamine (DA) is a critical component of the brain circuitry regulating behavioral
activation. Adenosine A2A antagonists reverse many of the behavioral effects of DA …

Here we report the development of D 1 A 2A receptor knockout mice to investigate whether
interactions between dopamine D 1 and adenosine A 2A receptors participate in reward …

The possible molecular basis for the previously described antagonistic interactions between
adenosine A1 receptors (A1R) and dopamine D1 receptors (D1R) in the brain have been …

Human adenosine A2A and rat dopamine D2 receptors (A2A and D2 receptors) were co-
transfected in Chinese hamster ovary (CHO) cells to study the interactions between two …

The structural and functional interaction between D2 dopamine receptor (DR) and A2A
adenosine receptor (AR) has suggested these two receptors as a pharmacological target in …

According to the adenosine hypothesis of schizophrenia, the classically associated
hyperdopaminergic state may be secondary to a loss of function of the adenosinergic …