Preladenant, a selective A2A receptor antagonist, is active in primate models of movement disorders
RA Hodgson, PJ Bedard, GB Varty, TM Kazdoba… - Experimental …, 2010 - Elsevier
Parkinson's Disease (PD) and Extrapyramidal Syndrome (EPS) are movement disorders that
result from degeneration of the dopaminergic input to the striatum and chronic inhibition of …
result from degeneration of the dopaminergic input to the striatum and chronic inhibition of …
Adenosine A1 receptor blockade selectively potentiates the motor effects induced by dopamine D1 receptor stimulation in rodents
P Popoli, L Giménez-Llort, A Pezzola, R Reggio… - Neuroscience …, 1996 - Elsevier
An antagonistic interaction between adenosine A1 and dopamine D1 receptors has
previously been found in the basal ganglia. However, direct evidence for a selective …
previously been found in the basal ganglia. However, direct evidence for a selective …
Allosteric mechanisms within the adenosine A2A–dopamine D2 receptor heterotetramer
The structure constituted by a G protein coupled receptor (GPCR) homodimer and a G
protein provides a main functional unit and oligomeric entities can be viewed as multiples of …
protein provides a main functional unit and oligomeric entities can be viewed as multiples of …
Biochemical identification of the dopamine D2 receptor domains interacting with the adenosine A2A receptor
M Torvinen, LB Kozell, KA Neve, LF Agnati… - Journal of Molecular …, 2004 - Springer
Functional interactions between adenosine A 2A and dopamine D 2 receptors have been
demonstrated both at the D 2 agonist-binding and second messenger levels. The present …
demonstrated both at the D 2 agonist-binding and second messenger levels. The present …
The mGlu5 Receptor Protomer-Mediated Dopamine D2 Receptor Trans-Inhibition Is Dependent on the Adenosine A2A Receptor Protomer: Implications for …
W Romero-Fernandez, JJ Taura, RAJ Crans… - Molecular …, 2022 - Springer
The adenosine A2A receptor (A2AR), dopamine D2 receptor (D2R) and metabotropic
glutamate receptor type 5 (mGluR5) form A2AR-D2R-mGluR5 heteroreceptor complexes in …
glutamate receptor type 5 (mGluR5) form A2AR-D2R-mGluR5 heteroreceptor complexes in …
Autocrine activation of adenosine A1 receptors blocks D1A but not D1B dopamine receptor desensitization
S Le Crom, D Prou, P Vernier - Journal of neurochemistry, 2002 - Wiley Online Library
Adenosine is known to modulate dopamine responses in several brain areas. Here, we
show that tonic activation of adenosine receptors is able to impede desensitization of D1 …
show that tonic activation of adenosine receptors is able to impede desensitization of D1 …
Mapping the Interface of a GPCR Dimer: A Structural Model of the A2A Adenosine and D2 Dopamine Receptor Heteromer
DO Borroto-Escuela, D Rodriguez… - Frontiers in …, 2018 - frontiersin.org
The A2A adenosine (A2AR) and D2 dopamine (D2R) receptors form oligomers in the cell
membrane and allosteric interactions across the A2AR–D2R heteromer represent a target …
membrane and allosteric interactions across the A2AR–D2R heteromer represent a target …
Striatal Pre- and Postsynaptic Profile of Adenosine A2A Receptor Antagonists
M Orru, J Bakešová, M Brugarolas, C Quiroz… - PLoS …, 2011 - journals.plos.org
Striatal adenosine A2A receptors (A2ARs) are highly expressed in medium spiny neurons
(MSNs) of the indirect efferent pathway, where they heteromerize with dopamine D2 …
(MSNs) of the indirect efferent pathway, where they heteromerize with dopamine D2 …
Cellular and behavioural effects of the adenosine A2a receptor antagonist KW‐6002 in a rat model of l‐DOPA‐induced dyskinesia
We have examined the ability of KW‐6002, an adenosine A2a antagonist, to modulate the
dyskinetic effects of l‐DOPA in 6‐hydroxydopamine‐lesioned rats. In animals rendered …
dyskinetic effects of l‐DOPA in 6‐hydroxydopamine‐lesioned rats. In animals rendered …
Characterization of the potent and highly selective A2A receptor antagonists preladenant and SCH 412348 [7-[2-[4-2, 4-difluorophenyl]-1-piperazinyl] ethyl]-2-(2 …
RA Hodgson, R Bertorelli, GB Varty… - … of Pharmacology and …, 2009 - ASPET
The adenosine A2A receptor has been implicated in the underlying biology of various
neurological and psychiatric disorders, including Parkinson's disease (PD) and depression …
neurological and psychiatric disorders, including Parkinson's disease (PD) and depression …