Therapeutic gene transfer, or “gene therapy” was originally proposed as a means of curing
heritable genetic defects through the transfer of a normal gene to replace the defective …

Pain encompasses a cruel irony. One of the most universal of human sensations, pain
seems nevertheless to lie beyond ordinary comprehension. Its cause has been ascribed to …

The use of gene transfer techniques, designed to effect the continuous release of analgesic
peptides, offers the possibility to treat what may otherwise be intractable pain. In this chapter …

Gene therapy has been studied extensively in the last two decades at least. In contrast to the
traditional use of low-molecular-weight drugs that usually have only a transient impact on …

Gene therapy was first proposed as an approach to the treatment of recessive inherited
disease, in which addition of a correct copy of the mutant gene would restore normal …

EDITORIAL Fink & Wolfe peptides, the endogenous agonists for the δ-opioid receptor. The
human clinical trial was preceded by preclinical studies that examined the effect of HSV …

A RECENT report from the Recombinant DNA Advisory Committee lists 393 approved
human gene therapy protocols (www. od. nih. gov/oba/documents. htm). Of these, 33 are for …

Neuropathic pain is notoriously difficult to treat; currently available pharmaceutical drugs
result in moderate analgesia in approximately a third of patients. As our understanding of the …

We interviewed several patients whose only options had been amputation to relieve severe
chronic pain. Dale McKitterick of Las Vegas was one of those. He had reached the end of …

Sensory polyneuropathy is a disabling condition for which there are no currently available
effective therapies. Chronic pain is a condition that, despite the availability of many treatment …