In-vitro blood-brain barrier models for drug screening and permeation studies: an overview
The blood-brain barrier (BBB) is comprised of brain microvascular endothelial central
nervous system (CNS) cells, which communicate with other CNS cells (astrocytes, pericytes) …
nervous system (CNS) cells, which communicate with other CNS cells (astrocytes, pericytes) …
Prediction of blood–brain barrier permeation in drug discovery from in vivo, in vitro and in silico models
NJ Abbott - Drug Discovery Today: Technologies, 2004 - Elsevier
The properties of the blood–brain barrier (BBB) are important considerations when
designing drugs to target or avoid the brain. In vivo models provide some of the most reliable …
designing drugs to target or avoid the brain. In vivo models provide some of the most reliable …
[HTML][HTML] Experimental models of in vitro blood–brain barrier for CNS drug delivery: an evolutionary perspective
Central nervous system (CNS) disorders represent one of the leading causes of global
health burden. Nonetheless, new therapies approved against these disorders are among …
health burden. Nonetheless, new therapies approved against these disorders are among …
In vitro blood–brain barrier models for drug research: state-of-the-art and new perspectives on reconstituting these models on artificial basement membrane platforms
Highlights•Drug penetration through the BBB is a major challenge for treating CNS
diseases.•In vitro BBB models are invaluable for evaluating drug transport into the …
diseases.•In vitro BBB models are invaluable for evaluating drug transport into the …
In vitro blood brain barrier models: An overview
E Jagtiani, M Yeolekar, S Naik, V Patravale - Journal of Controlled Release, 2022 - Elsevier
Understanding the composition and function of the blood brain barrier (BBB) enables the
development of novel, innovative techniques for administering central nervous system …
development of novel, innovative techniques for administering central nervous system …
Blood-brain barrier models: Rationale for selection
AS Hanafy, D Dietrich, G Fricker… - Advanced Drug Delivery …, 2021 - Elsevier
Brain delivery is a broad research area, the outcomes of which are far hindered by the
limited permeability of the blood–brain barrier (BBB). Over the last century, research has …
limited permeability of the blood–brain barrier (BBB). Over the last century, research has …
Blood–brain barrier models and their relevance for a successful development of CNS drug delivery systems: a review
During the research and development of new drugs directed at the central nervous system,
there is a considerable attrition rate caused by their hampered access to the brain by the …
there is a considerable attrition rate caused by their hampered access to the brain by the …
Blood–brain barrier models: in vitro to in vivo translation in preclinical development of CNS-targeting biotherapeutics
DB Stanimirovic, M Bani-Yaghoub… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: The majority of therapeutics, small molecule or biologics, developed for the
CNS do not penetrate the blood–brain barrier (BBB) sufficiently to induce pharmacologically …
CNS do not penetrate the blood–brain barrier (BBB) sufficiently to induce pharmacologically …
Blood–brain barrier structure and function and the challenges for CNS drug delivery
NJ Abbott - Journal of inherited metabolic disease, 2013 - Springer
The neurons of the central nervous system (CNS) require precise control of their bathing
microenvironment for optimal function, and an important element in this control is the blood …
microenvironment for optimal function, and an important element in this control is the blood …
A human immortalized cell-based blood–brain barrier triculture model: development and characterization as a promising tool for drug− brain permeability studies
R Ito, K Umehara, S Suzuki, K Kitamura… - Molecular …, 2019 - ACS Publications
Brain microvascular endothelial cells (BMEC), together with astrocytes and pericytes, form
the blood–brain barrier (BBB) that strictly restricts drug penetration into the brain. Therefore …
the blood–brain barrier (BBB) that strictly restricts drug penetration into the brain. Therefore …