Apoptosis induction by MEK inhibition in human lung cancer cells is mediated by Bim
J Meng, B Fang, Y Liao, CM Chresta, PD Smith… - PloS one, 2010 - journals.plos.org
AZD6244 (ARRY-142886) is an inhibitor of MEK1/2 and can inhibit cell proliferation or
induce apoptosis in a cell-type dependent manner. The precise molecular mechanism of …
induce apoptosis in a cell-type dependent manner. The precise molecular mechanism of …
BIM induction of apoptosis triggered by EGFR-sensitive and resistance cell lines of non-small-cell lung cancer
Z Li, S Zhou, L Zhang, C Su, J Hang, Y Zhao, B Su… - Medical Oncology, 2011 - Springer
We sought to improve the understanding of oncogene-dependent and independent non-
small-cell lung cancer (NSCLC), which could provide insight into mechanism of sensitivity …
small-cell lung cancer (NSCLC), which could provide insight into mechanism of sensitivity …
Bim is reversibly phosphorylated but plays a limited role in paclitaxel cytotoxicity of breast cancer cell lines
M Czernick, A Rieger, S Goping - Biochemical and biophysical research …, 2009 - Elsevier
The chemotherapeutic drug, paclitaxel, induces mitotic arrest and then activates the cellular
apoptotic program. Although paclitaxel has been in clinical use for over 10 years for the …
apoptotic program. Although paclitaxel has been in clinical use for over 10 years for the …
Piperlongumine-induced nuclear translocation of the FOXO3A transcription factor triggers BIM-mediated apoptosis in cancer cells
Z Liu, Z Shi, J Lin, S Zhao, M Hao, J Xu, Y Li… - Biochemical …, 2019 - Elsevier
The transcription factor forkhead box O 3A (FOXO3A) is a tumor suppressor that promotes
cell cycle arrest and apoptosis. Piperlongumine (PL), a plant alkaloid, is known to selectively …
cell cycle arrest and apoptosis. Piperlongumine (PL), a plant alkaloid, is known to selectively …
FOXO1 and FOXO3a sensitize non-small-cell lung cancer cells to cisplatin-induced apoptosis independent of Bim
T Sun, J Zhang, B Deng, X Fan, T Long… - Acta Biochimica et …, 2020 - academic.oup.com
Low sensitivity to chemotherapy has been a major challenge in the treatment of non-small-
cell lung cancer (NSCLC). It is of great clinical significance to discover its mechanisms to …
cell lung cancer (NSCLC). It is of great clinical significance to discover its mechanisms to …
Direct transcriptional regulation of Bim by FoxO3a mediates STI571-induced apoptosis in Bcr-Abl-expressing cells
A Essafi, S Fernández de Mattos, YAM Hassen… - Oncogene, 2005 - nature.com
In this study, we have used the human BV173 and the mouse BaF3/Bcr-Abl-expressing cell
lines as model systems to investigate the molecular mechanisms whereby STI571 and …
lines as model systems to investigate the molecular mechanisms whereby STI571 and …
Bim directly antagonizes Bcl-xl in doxorubicin-induced prostate cancer cell apoptosis independently of p53
Doxorubicin and other anthracycline compounds exert their anti-cancer effects by causing
DNA damage and initiating cell cycle arrest in cancer cells, followed by apoptosis. DNA …
DNA damage and initiating cell cycle arrest in cancer cells, followed by apoptosis. DNA …
Apoptosis of non-small-cell lung cancer cell lines after paclitaxel treatment involves the BH3-only proapoptotic protein Bim
R Li, T Moudgil, HJ Ross, HM Hu - Cell Death & Differentiation, 2005 - nature.com
A significant variation in susceptibility to paclitaxel-mediated killing was observed among a
panel of short-term cultured non-small-cell lung cancer (NSCLC) cell lines. Susceptibility to …
panel of short-term cultured non-small-cell lung cancer (NSCLC) cell lines. Susceptibility to …
Phosphorylation of Bim-EL by Erk1/2 on serine 69 promotes its degradation via the proteasome pathway and regulates its proapoptotic function
F Luciano, A Jacquel, P Colosetti, M Herrant, S Cagnol… - Oncogene, 2003 - nature.com
Bim is a proapoptotic member of the Bcl-2 family that shares only the BH3 domain with this
family. Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized from the same …
family. Three Bim proteins Bim-EL, Bim-L and Bim-S are synthesized from the same …
The novel anti-MEK small molecule AZD6244 induces BIM-dependent and AKT-independent apoptosis in diffuse large B-cell lymphoma
Abstract The RAS/RAF/MEK/ERK signaling pathway has been largely unexplored as a
potential therapeutic target in lymphoma. The novel 2nd generation anti-MEK small …
potential therapeutic target in lymphoma. The novel 2nd generation anti-MEK small …