A Co-Doped Fe3O4 Nanozyme Shows Enhanced Reactive Oxygen and Nitrogen Species Scavenging Activity and Ameliorates the Deleterious Effects of Ischemic …

Y Liu, X Wang, X Li, S Qiao, G Huang… - … Applied Materials & …, 2021 - ACS Publications
Acute ischemic stroke has become the major cause of mortality and disability worldwide.
Following ischemic stroke, the reperfusion injury is mainly mediated by the burst of reactive …

Dietary Fe3O4 Nanozymes Prevent the Injury of Neurons and Blood–Brain Barrier Integrity from Cerebral Ischemic Stroke

BC Yan, J Cao, J Liu, Y Gu, Z Xu, D Li… - … biomaterials science & …, 2020 - ACS Publications
Cerebral ischemic stroke stimulates excessive reactive oxygen species, which lead to blood–
brain-barrier disruption, neuron death, and aggravated cerebral infarction. Thus, it is critical …

Bioactive nanoenzyme reverses oxidative damage and endoplasmic reticulum stress in neurons under ischemic stroke

G Huang, J Zang, L He, H Zhu, J Huang, Z Yuan… - ACS …, 2021 - ACS Publications
Designing translational antioxidative agents that could scavenge free radicals produced
during reperfusion in brain ischemia stroke and alleviate neurologic damage is the main …

Transferrin-Enabled Blood–Brain Barrier Crossing Manganese-Based Nanozyme for Rebalancing the Reactive Oxygen Species Level in Ischemic Stroke

Q Zhao, W Du, L Zhou, J Wu, X Zhang, X Wei, S Wang… - Pharmaceutics, 2022 - mdpi.com
(1) Background: Acute ischemic stroke (IS) is one of the main causes of human disability and
death. Therefore, multifunctional nanosystems that effectively cross the blood–brain barrier …

An ischemia-homing bioengineered nano-scavenger for specifically alleviating multiple pathogeneses in ischemic stroke

R Duan, K Sun, F Fang, N Wang, R He, Y Gao… - Journal of …, 2022 - Springer
Background Ischemic stroke is one of the most serious global public health problems.
However, the performance of current therapeutic regimens is limited due to their poor target …

[HTML][HTML] Advances in antioxidative nanozymes for treating ischemic stroke

J Shan, X Liu, X Li, Y Yu, B Kong, L Ren - Engineered Regeneration, 2023 - Elsevier
Ischemic stroke is one of the most common public diseases that increase mortality. In the
ischemic brain, blood flow restoration can cause the generation of excess reactive oxygen …

[HTML][HTML] Catalytic patch with redox Cr/CeO2 nanozyme of noninvasive intervention for brain trauma

S Zhang, Y Liu, S Sun, J Wang, Q Li, R Yan, Y Gao… - Theranostics, 2021 - ncbi.nlm.nih.gov
Traumatic brain injury (TBI) is a sudden injury to the brain, accompanied by the production of
large amounts of reactive oxygen and nitrogen species (RONS) and acute …

Se‐Containing MOF Coated Dual‐Fe‐Atom Nanozymes With Multi‐Enzyme Cascade Activities Protect Against Cerebral Ischemic Reperfusion Injury

R Tian, H Ma, W Ye, Y Li, S Wang… - Advanced Functional …, 2022 - Wiley Online Library
The atomically monodispersed dual‐atom nanozyme not only possesses the advantages of
homogeneous active centers and high atomic utilization efficiency but also exhibits amazing …

Single-atom cobalt nanozymes promote spinal cord injury recovery by anti-oxidation and neuroprotection

Y Jiang, H Rong, Y Wang, S Liu, P Xu, Z Luo, L Guo… - Nano Research, 2023 - Springer
Oxidative stress and inflammation are central pathophysiological processes in a traumatic
spinal cord injury (SCI). Antioxidant therapies that reduce the reactive oxygen and nitrogen …

A Bioinspired Manganese‐Organic Framework Ameliorates Ischemic Stroke through its Intrinsic Nanozyme Activity and Upregulating Endogenous Antioxidant …

J Wang, Y Wang, X Xiaohalati, Q Su, J Liu… - Advanced …, 2023 - Wiley Online Library
Following stroke, oxidative stress induced by reactive oxygen species (ROS) aggravates
neuronal damage and enlarges ischemic penumbra, which is devastating to stroke patients …