Background Antibiotic exposure in intensive care patients with sepsis is frequently
inadequate and is associated with poorer outcomes. Antibiotic dosing is challenging in the …

Introduction Although early institution of adequate antimicrobial therapy is lifesaving in
sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the …

Introduction Several reports have shown marked heterogeneity of antibiotic
pharmacokinetics (PK) in patients admitted to ICUs, which might potentially affect outcomes …

Introduction Costs are one of the factors determining physicians' choice of medication to
treat patients in specific situations. However, usually only the drug acquisition costs are …

Introduction The use of standard doses of β-lactam antibiotics during continuous renal
replacement therapy (CRRT) may result in inadequate serum concentrations. The aim of this …

Introduction Sepsis is responsible for important alterations in the pharmacokinetics of
antibiotics. Continuous renal replacement therapy (CRRT), which is commonly used in …

Introduction A rational use of antibiotics is of paramount importance in order to prevent the
emergence of multidrug resistant bacteria that can lead to therapeutic impasse, especially in …

Background Early appropriate antibiotic treatment is essential in sepsis. We aimed to
evaluate the impact of a multifaceted educational intervention to improve antibiotic …

Introduction It has been proposed that doses of amikacin of> 15 mg/kg should be used in
conditions associated with an increased volume of distribution (V d), such as severe sepsis …

Introduction In patients with severe sepsis and septic shock as cause of Intensive Care Unit
(ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy …