Trypanosoma cruzi Infection through the Oral Route Promotes a Severe Infection in Mice: New Disease Form from an Old Infection?

J Barreto-de-Albuquerque… - PLoS neglected …, 2015 - journals.plos.org
Oral transmission of Chagas disease has been documented in Latin American countries.
Nevertheless, significant studies on the pathophysiology of this form of infection are largely …

Unraveling Chagas disease transmission through the oral route: Gateways to Trypanosoma cruzi infection and target tissues

D Silva-dos-Santos… - PLoS neglected …, 2017 - journals.plos.org
Oral transmission of Trypanosoma cruzi, the causative agent of Chagas disease, is the most
important route of infection in Brazilian Amazon and Venezuela. Other South American …

Oral Versus Intragastric Inoculation: Similar Pathways of Trypanosoma cruzi Experimental Infection? From Target Tissues, Parasite Evasion, and Immune Response

J Barreto de Albuquerque, D Silva dos Santos… - Frontiers in …, 2018 - frontiersin.org
Currently, oral infection is the most frequent transmission mechanism of Chagas disease in
Brazil and others Latin American countries. This transmission pathway presents increased …

Host cell invasion and oral infection by Trypanosoma cruzi strains of genetic groups TcI and TcIV from chagasic patients

FY Maeda, TM Clemente, S Macedo, C Cortez… - Parasites & …, 2016 - Springer
Abstract Background Outbreaks of acute Chagas disease by oral infection have been
reported frequently over the last ten years, with higher incidence in northern South America …

Understanding the oral transmission of Trypanosoma cruzi as a veterinary and medical foodborne zoonosis

N Velásquez-Ortiz, JD Ramírez - Research in veterinary science, 2020 - Elsevier
Chagas disease is a neglected tropical disease transmitted by the protozoan Trypanosoma
cruzi that lately has been highlighted because several outbreaks attributed to oral …

Interaction with host factors exacerbates Trypanosoma cruzi cell invasion capacity upon oral infection

C Covarrubias, M Cortez, D Ferreira… - International journal for …, 2007 - Elsevier
Outbreaks of severe acute Chagas' disease acquired by oral infection, leading to death in
some cases, have occurred in recent years. Using the mouse model, we investigated the …

Oral Exposure to Trypanosoma cruzi Elicits a Systemic CD8+ T Cell Response and Protection against Heterotopic Challenge

MH Collins, JM Craft, JM Bustamante… - Infection and …, 2011 - Am Soc Microbiol
Trypanosoma cruzi infects millions of people in Latin America and often leads to the
development of Chagas disease. T. cruzi infection can be acquired at or near the bite site of …

Trypanosoma cruzi Entrance through Systemic or Mucosal Infection Sites Differentially Modulates Regional Immune Response Following Acute Infection in Mice

J de Meis, J Barreto de Albuquerque… - Frontiers in …, 2013 - frontiersin.org
Acute Chagas disease is characterized by a systemic infection that leads to the strong
activation of the adaptive immune response. Outbreaks of oral contamination by the infective …

Congenital and oral transmission of American trypanosomiasis: an overview of physiopathogenic aspects

LV Sánchez, JD Ramírez - Parasitology, 2013 - cambridge.org
Chagas disease or American trypanosomiasis is a pathology affecting about 8–11 million
people in Mexico, Central America, and South America, more than 300 000 persons in the …

Outcome of oral infection in mice inoculated with Trypanosoma cruzi IV of the Western Brazilian Amazon

APM Teston, AP de Abreu, CP Abegg, ML Gomes… - Acta tropica, 2017 - Elsevier
A new epidemiological view of American trypanosomiasis or Chagas disease has been
formulated in recent decades. Oral transmission of the etiological agent of Chagas disease …