p38 inhibition provides anti–DNA virus immunity by regulation of USP21 phosphorylation and STING activation
Y Chen, L Wang, J Jin, Y Luan, C Chen, Y Li… - Journal of Experimental …, 2017 - rupress.org
Stimulator of IFN genes (STING) is a central adaptor protein that mediates the innate
immune responses to DNA virus infection. Although ubiquitination is essential for STING …
immune responses to DNA virus infection. Although ubiquitination is essential for STING …
USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA
M Zhang, MX Zhang, Q Zhang, GF Zhu, L Yuan… - Cell Research, 2016 - nature.com
STING (also known as MITA) mediates the innate antiviral signaling and ubiquitination of
STING is key to its function. However, the deubiquitination process of STING is unclear. Here …
STING is key to its function. However, the deubiquitination process of STING is unclear. Here …
USP13 negatively regulates antiviral responses by deubiquitinating STING
H Sun, Q Zhang, YY Jing, M Zhang, HY Wang… - Nature …, 2017 - nature.com
STING (also known as MITA) is critical for host defence against viruses and the activity of
STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully …
STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully …
The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway
Stimulator of interferon genes (STING) is critical for cytosolic DNA-triggered innate immunity.
STING is modified by several types of polyubiquitin chains. Here, we report that the …
STING is modified by several types of polyubiquitin chains. Here, we report that the …
USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA
L Ye, Q Zhang, T Liuyu, Z Xu, MX Zhang… - PLoS …, 2019 - journals.plos.org
Mediator of IRF3 activation (MITA, also known as STING and ERIS) is an essential adaptor
protein for cytoplasmic DNA-triggered signaling and involved in innate immune responses …
protein for cytoplasmic DNA-triggered signaling and involved in innate immune responses …
[HTML][HTML] The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING
Stimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for
host immune responses triggered by microbial DNAs. However, the regulatory mechanisms …
host immune responses triggered by microbial DNAs. However, the regulatory mechanisms …
UFL1 promotes antiviral immune response by maintaining STING stability independent of UFMylation
Y Tao, S Yin, Y Liu, C Li, Y Chen, D Han… - Cell Death & …, 2023 - nature.com
The precise regulation of STING homeostasis is essential for its antiviral function. Post-
translational modification, especially ubiquitination, is important for the regulation of STING …
translational modification, especially ubiquitination, is important for the regulation of STING …
UNC93B1 attenuates the cGAS–STING signaling pathway by targeting STING for autophagy–lysosome degradation
H Zhu, R Zhang, L Yi, YD Tang… - Journal of Medical …, 2022 - Wiley Online Library
Stimulator of interferon genes (STING) is a pivotal innate immune adaptor, and its functions
during DNA virus infections have been extensively documented. However, its homeostatic …
during DNA virus infections have been extensively documented. However, its homeostatic …
Interferon-independent STING signaling promotes resistance to HSV-1 in vivo
LH Yamashiro, SC Wilson, HM Morrison… - Nature …, 2020 - nature.com
Abstract The Stimulator of Interferon Genes (STING) pathway initiates potent immune
responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C …
responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C …
USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA
HY Zhang, BW Liao, ZS Xu, Y Ran, DP Wang… - PLoS …, 2020 - journals.plos.org
Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING)
senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA …
senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA …