p38 inhibition provides anti–DNA virus immunity by regulation of USP21 phosphorylation and STING activation

Y Chen, L Wang, J Jin, Y Luan, C Chen, Y Li… - Journal of Experimental …, 2017 - rupress.org
Stimulator of IFN genes (STING) is a central adaptor protein that mediates the innate
immune responses to DNA virus infection. Although ubiquitination is essential for STING …

USP18 recruits USP20 to promote innate antiviral response through deubiquitinating STING/MITA

M Zhang, MX Zhang, Q Zhang, GF Zhu, L Yuan… - Cell Research, 2016 - nature.com
STING (also known as MITA) mediates the innate antiviral signaling and ubiquitination of
STING is key to its function. However, the deubiquitination process of STING is unclear. Here …

USP13 negatively regulates antiviral responses by deubiquitinating STING

H Sun, Q Zhang, YY Jing, M Zhang, HY Wang… - Nature …, 2017 - nature.com
STING (also known as MITA) is critical for host defence against viruses and the activity of
STING is regulated by ubiquitination. However, the deubiquitination of STING is not fully …

The deubiquitinase CYLD is a specific checkpoint of the STING antiviral signaling pathway

L Zhang, N Wei, Y Cui, Z Hong, X Liu, Q Wang… - PLoS …, 2018 - journals.plos.org
Stimulator of interferon genes (STING) is critical for cytosolic DNA-triggered innate immunity.
STING is modified by several types of polyubiquitin chains. Here, we report that the …

USP49 negatively regulates cellular antiviral responses via deconjugating K63-linked ubiquitination of MITA

L Ye, Q Zhang, T Liuyu, Z Xu, MX Zhang… - PLoS …, 2019 - journals.plos.org
Mediator of IRF3 activation (MITA, also known as STING and ERIS) is an essential adaptor
protein for cytoplasmic DNA-triggered signaling and involved in innate immune responses …

[HTML][HTML] The E3 ubiquitin ligase AMFR and INSIG1 bridge the activation of TBK1 kinase by modifying the adaptor STING

Q Wang, X Liu, Y Cui, Y Tang, W Chen, S Li, H Yu… - Immunity, 2014 - cell.com
Stimulator of interferon genes (STING, also known as MITA, ERIS, or MPYS) is essential for
host immune responses triggered by microbial DNAs. However, the regulatory mechanisms …

UFL1 promotes antiviral immune response by maintaining STING stability independent of UFMylation

Y Tao, S Yin, Y Liu, C Li, Y Chen, D Han… - Cell Death & …, 2023 - nature.com
The precise regulation of STING homeostasis is essential for its antiviral function. Post-
translational modification, especially ubiquitination, is important for the regulation of STING …

UNC93B1 attenuates the cGAS–STING signaling pathway by targeting STING for autophagy–lysosome degradation

H Zhu, R Zhang, L Yi, YD Tang… - Journal of Medical …, 2022 - Wiley Online Library
Stimulator of interferon genes (STING) is a pivotal innate immune adaptor, and its functions
during DNA virus infections have been extensively documented. However, its homeostatic …

Interferon-independent STING signaling promotes resistance to HSV-1 in vivo

LH Yamashiro, SC Wilson, HM Morrison… - Nature …, 2020 - nature.com
Abstract The Stimulator of Interferon Genes (STING) pathway initiates potent immune
responses upon recognition of DNA. To initiate signaling, serine 365 (S365) in the C …

USP44 positively regulates innate immune response to DNA viruses through deubiquitinating MITA

HY Zhang, BW Liao, ZS Xu, Y Ran, DP Wang… - PLoS …, 2020 - journals.plos.org
Mediator of IRF3 activation (MITA, also known as stimulator of interferon genes, STING)
senses the second messenger cyclic GMP-AMP (cGAMP) which is synthesized upon DNA …