Abstract Hyper Immunoglobulin M syndrome (HIGM) is a rare primary immunodeficiency
disorder characterized by low or absent levels of serum IgG, IgA, IgE and normal or …

Abstract Purpose The United States Immunodeficiency Network (USIDNET) patient registry
was used to characterize the presentation, genetics, phenotypes, and treatment of patients …

The hyper IgM syndromes are a group of rare inherited immune deficiency disorders
characterized by impairment of immunoglobulin isotype switching resulting from defects in …

Abstract Introduction Immunodeficiency with hyper-IgM (HIGM) results from genetic defects
in the CD40–CD40 ligand (CD40L) pathway or in the enzymes required for immunoglobulin …

Hyper-IgM (HIGM) syndrome is a heterogeneous group of disorders characterized by normal
or elevated serum IgM levels associated with absent or decreased IgG, IgA and IgE. Here …

Hyper-IgM syndrome (HIGM) is a rare primary immunodeficiency disorder characterized by
elevated or normal serum IgM and decreased IgG, IgA, and IgE due to defective …

Abstract Background Hyper-immunoglobulin M (HIGM) syndromes are a heterogeneous
group of primary immunodeficiency disorders, characterized by recurrent infections …

The primary immunodeficiency (PID) diseases comprise a heterogeneous group of inherited
disorders of immune function. Technical advancements in whole-genome, whole-exome …

The inability to initiate switching from one immunoglobulin isotype to another is the hallmark
of the hyper-IgM immunodeficiency syndrome1. Patients with this primary immune disorder …

X‐linked hyper‐IgM syndrome (XHIM), or hyper‐IgM syndrome type 1 (HIGM1), is a rare
primary immunodeficiency disorder susceptible to recurrent bacterial infection and …