Recent publications purporting to show that calcium antagonists, when used for the
treatment of hypertension or in the post myocardial infarction patient, would paradoxically …

The goal of the treatment of hypertension is to reduce the risk of the cardiovascular
complications--stroke, acute myocardial infarction, congestive heart failure and renal …

This opinion has been challenged by the publication in the USA of three papers, by Psaty et
al.[1], Furberg et al.[2] and Pahor et al.[3]. These papers report that, in both hypertension and …

Pi. rnce their introduction over 25 years ago, calcium antagonists have emerged as one of
the most attractive and widelv used classes of an-42, trhypertensive agents. Of the 20 to 25 …

Background Periodically in the history of antihypertensive therapy, minor storms have
significantly affected the use of entire classes of agents. An early example is the publication …

Calcium antagonists reduce the influx of calcium ions through the calcium channels. This
causes a reduction in myocardial contractility or a fall in vascular resistance because of a …

Calcium antagonists reprint a diverse group of therapeutic agents with heterogenous
pharmacologic, pharmacokinetic, and pharmacodynamic properties. It seems clear that the …

The ACTION trial was a multicentre, double-blind, randomized, placebo-controlled trial in
which the effect of long-acting nifedipine GITS (Gastrointestinal Therapeutic System) on …

The controversy over the efficacy and safety of calcium antagonists is over 2 years old. Since
millions of patients worldwide are currently using calcium antagonists for the treatment of …

A recent report of an increased risk of myocardial infarction in hypertensive patients treated
with calcium antagonists was presented at the 35th Annual Conference on Cardiovascular …