Idiopathic pulmonary fibrosis: recent advances on pharmacological therapy

P Spagnolo, TM Maher, L Richeldi - Pharmacology & therapeutics, 2015 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is the most common and lethal of the idiopathic interstitial
pneumonias with an estimated 5-year survival of approximately 20%. In the last two decades …

Idiopathic pulmonary fibrosis: Disease mechanisms and drug development

P Spagnolo, JA Kropski, MG Jones, JS Lee… - Pharmacology & …, 2021 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause
characterized by relentless scarring of the lung parenchyma leading to reduced quality of life …

Idiopathic pulmonary fibrosis: an update

P Spagnolo, N Sverzellati, G Rossi, A Cavazza… - Annals of …, 2015 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is the most common and lethal form of idiopathic
interstitial pneumonia. The disease, which occurs primarily in middle-aged and older adults …

The big clinical trials in idiopathic pulmonary fibrosis

F Luppi, P Spagnolo, S Cerri… - Current opinion in …, 2012 - journals.lww.com
Despite multiple clinical trials, there is no strong, definitive evidence in favor of any agent to
treat IPF. On the other hand, the placebo arms of these large trials have provided us with …

Idiopathic pulmonary fibrosis: new and emerging treatment options

RJ Hewitt, TM Maher - Drugs & Aging, 2019 - Springer
Idiopathic pulmonary fibrosis (IPF) is a progressive and debilitating, scarring lung disease
with a worse prognosis than some cancers. The incidence of IPF is increasing and while …

Pharmacological treatment of idiopathic pulmonary fibrosis: current approaches, unsolved issues, and future perspectives

M Kreuter, F Bonella, M Wijsenbeek… - BioMed research …, 2015 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a devastating condition with a 5‐year survival of
approximately 20%. The disease primarily occurs in elderly patients. IPF is a highly …

Idiopathic pulmonary fibrosis: current treatment options and critical appraisal of nintedanib

F Bonella, S Stowasser, L Wollin - Drug design, development and …, 2015 - Taylor & Francis
Idiopathic pulmonary fibrosis (IPF) is the most common type of idiopathic interstitial
pneumonia and is characterized by a poor prognosis, with an estimated 5-year survival of …

A new era in idiopathic pulmonary fibrosis: considerations for future clinical trials

HR Collard, WZ Bradford, V Cottin… - European …, 2015 - Eur Respiratory Soc
The past decade has seen substantial progress in understanding the pathobiology, natural
history, and clinical significance of idiopathic pulmonary fibrosis (IPF), culminating in the …

An update on emerging drugs for the treatment of idiopathic pulmonary fibrosis

S Aryal, SD Nathan - Expert opinion on emerging drugs, 2018 - Taylor & Francis
Introduction: Idiopathic pulmonary fibrosis is a chronic, progressive fibrotic lung disease of
unknown etiology associated with a high morbidity and mortality. The hallmark of the …

Pharmacological management of idiopathic pulmonary fibrosis: current and emerging options

A Trachalaki, M Irfan, AU Wells - Expert Opinion on …, 2021 - Taylor & Francis
ABSTRACT Introduction Idiopathic Pulmonary Fibrosis is a chronic, progressive lung
disease characterized by worsening lung scarring and the radiological/histological pattern of …