Purpose To investigate whether the blood-brain barrier (BBB) leaks blood-circulating
substances in patients with early forms of Alzheimer disease (AD), and if so, to examine the …

Blood-brain barrier (BBB) dysfunction may contribute to the risk of Alzheimer's disease (AD).
Dynamic contrast-enhanced magnetic resonance imaging (MRI) was performed repeatedly …

To investigate whether blood–brain barrier (BBB) disruption is a potential mechanism of
usual age-related cognitive decline, we conducted dynamic contrast–enhanced (DCE) MRI …

Purpose Dynamic contrast‐enhanced (DCE) MRI can be used to measure blood‐brain
barrier (BBB) leakage. In neurodegenerative disorders such as small vessel disease and …

Objective Blood–brain barrier (BBB) breakdown has been suggested to be an early
biomarker in human cognitive impairment. However, the relationship between BBB …

The neurovascular unit, which protects neuronal cells and supplies them with essential
molecules, plays an important role in the pathophysiology of Alzheimer's Disease (AD). The …

Blood–brain barrier (BBB) breakdown can disrupt nutrient supply and waste removal, which
affects neuronal functioning. Currently, dynamic contrast-enhanced (DCE) MRI is the …

Background Blood-brain barrier (BBB) breakdown, as an early biomarker for vascular mild
cognitive impairment (vMCI), has only been validated by a few studies. The aim of this study …

Impairment of the blood brain barrier (BBB) in human brain ageing and its relationship to
Alzheimer-type pathology remains poorly defined. We have investigated the BBB in …

Blood-brain barrier (BBB) leakage is considered an important underlying process in both
cerebral small vessel disease (cSVD) and Alzheimer's disease (AD). The objective of this …