Positron emission tomography with [68Ga] ethylenediaminetetraacetic acid ([68Ga] EDTA)
was used to examine the integrity of the blood–brain barrier (BBB) in five patients with …

The blood–brain barrier (BBB) is the principal regulator of blood-borne substance entry into
the brain parenchyma. Therefore, BBB leakage, which leads to cerebral edema and influx of …

Introduction We examined whether cortical microvascular blood volume and hemodynamics
in Alzheimer's disease (AD) are consistent with tissue hypoxia and whether they correlate …

Background Reduced cerebral blood flow (CBF) contributes to the pathophysiology of
Alzheimer's disease (AD). However, it is unclear whether there is a spatial-temporal-specific …

The blood-brain barrier (BBB) is a complex and dynamic physiological interface between
brain parenchyma and cerebral vasculature. It is composed of closely interacting cells and …

Cerebral small vessel disease (cSVD) comprises pathological processes of the small
vessels in the brain that may manifest clinically as stroke, cognitive impairment, dementia, or …

Background and aim The pathogenesis of cerebral small-vessel disease (SVD) is
incompletely understood. Endothelial dysfunction has been implicated and may result in …

Objectives To examine the association between blood-brain barrier (BBB) integrity, brain
volume and cognitive dysfunction in adult patients with systemic lupus erythematosus (SLE) …

Background: The pathophysiology underlying altered blood-cerebrospinal fluid barrier
(BCSFB) function in Alzheimer's disease (AD) is unknown but may relate to endothelial cell …