A method for the preparation and GC− TOF-MS analysis of human serum samples has been
developed and evaluated for application in long-term metabolomic studies. Serum samples …

A method for performing untargeted metabolomic analysis of human serum has been
developed based on protein precipitation followed by Ultra Performance Liquid …

Sample preparation remains a challenge in untargeted metabolomics studies and no
method currently results in complete extraction of all metabolite classes in human plasma …

Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

This work aims at evaluating the relevance and versatility of liquid chromatography coupled
to high resolution mass spectrometry (LC/HRMS) for performing a qualitative and …

For the first time it is possible to simultaneously collect targeted and nontargeted
metabolomics data from plasma based on GC with high scan speed tandem mass …

Untargeted metabolomics refers to the high-throughput analysis of the metabolic state of a
biological system (eg, tissue, biological fluid, cell culture) based on the concentration profile …

A critical question facing the field of metabolomics is whether data obtained from different
centers can be effectively compared and combined. An important aspect of this is the …

The aim of metabolite profiling is to monitor all metabolites within a biological sample for
applications in basic biochemical research as well as pharmacokinetic studies and …

Gas chromatography–mass spectrometry (GC‐MS)–based metabolomics is ideal for
identifying and quantitating small‐molecule metabolites (< 650 Da), including small acids …