Multi‐omics data reveals novel impacts of human papillomavirus integration on the epigenomic and transcriptomic signatures of cervical tumorigenesis

X Zeng, Y Wang, B Liu, X Rao, C Cao… - Journal of Medical …, 2023 - Wiley Online Library
Integration of human papilloma virus (HPV) DNA into the human genome may progressively
contribute to cervical carcinogenesis. To explore how HPV integration affects gene …

Genomic structures and regulation patterns at HPV integration sites in cervical cancer

VL Porter, K O'Neill, S MacLennan, RD Corbett, M Ng… - bioRxiv, 2023 - biorxiv.org
Human papillomavirus (HPV) integration has been implicated in transforming HPV infection
into cancer, but its genomic consequences have been difficult to study using short-read …

[HTML][HTML] Multiple-integrations of HPV16 genome and altered transcription of viral oncogenes and cellular genes are associated with the development of cervical …

X Lu, Q Lin, M Lin, P Duan, L Ye, J Chen, X Chen… - PLoS …, 2014 - journals.plos.org
The constitutive expression of the high-risk HPV E6 and E7 viral oncogenes is the major
cause of cervical cancer. To comprehensively explore the composition of HPV16 early …

Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer

M Liu, Z Han, Y Zhi, Y Ruan, G Cao, G Wang, X Xu… - Translational …, 2023 - Elsevier
Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …

[HTML][HTML] Multi-omics characterization of silent and productive HPV integration in cervical cancer

J Fan, Y Fu, W Peng, X Li, Y Shen, E Guo, F Lu, S Zhou… - Cell Genomics, 2023 - cell.com
Cervical cancer (CC) that is caused by high-risk human papillomavirus (HPV) remains a
significant public health problem worldwide. HPV integration sites can be silent or actively …

Characteristic of HPV integration in the genome and transcriptome of cervical cancer tissues

W Li, Y Qi, X Cui, Q Huo, L Zhu, A Zhang… - BioMed research …, 2018 - Wiley Online Library
High‐risk HPV is clearly associated with cervical cancer. HPV integration has been
confirmed to promote carcinogenesis in the previous studies. In our study, a total of 285 DNA …

Simultaneous characterization of somatic events and HPV-18 integration in a metastatic cervical carcinoma patient using DNA and RNA sequencing

WS Liang, J Aldrich, S Nasser, A Kurdoglu… - International Journal of …, 2014 - ijgc.bmj.com
Objective Integration of carcinogenic human papillomaviruses (HPVs) into the host genome
is a significant tumorigenic factor in specific cancers including cervical carcinoma. Although …

[HTML][HTML] Mechanistic signatures of HPV insertions in cervical carcinomas

A Holmes, S Lameiras, E Jeannot, Y Marie… - NPJ genomic …, 2016 - nature.com
To identify new personal biomarkers for the improved diagnosis, prognosis and biological
follow-up of human papillomavirus (HPV)-associated carcinomas, we developed a generic …

[HTML][HTML] HPVbase–a knowledgebase of viral integrations, methylation patterns and microRNAs aberrant expression: As potential biomarkers for Human …

A Kumar Gupta, M Kumar - Scientific reports, 2015 - nature.com
Human papillomaviruses (HPVs) are extremely associated with different carcinomas.
Despite consequential accomplishments, there is still need to establish more promising …

Multi-omics mapping of human papillomavirus integration sites illuminates novel cervical cancer target genes

M Iden, SW Tsaih, YW Huang, P Liu, M Xiao… - British Journal of …, 2021 - nature.com
Background Integration of human papillomavirus (HPV) into the host genome is a dominant
feature of invasive cervical cancer (ICC), yet the tumorigenicity of cis genomic changes at …