Rat lung response to ozone and fine particulate matter (PM2.5) exposures

G Wang, J Zhao, R Jiang, W Song - Environmental toxicology, 2015 - Wiley Online Library
Exposure to different ambient pollutants maybe more toxic to lung than exposure to a single
pollutant. In this study, we discussed the inflammation and oxidative stress responses of rat …

The influence of PM2. 5 on lung injury and cytokines in mice

J Yang, Y Chen, Z Yu, H Ding… - Experimental and …, 2019 - spandidos-publications.com
Exposure to particulate matter≤ 2.5 µm in diameter (PM2. 5) profoundly affects human
health. However, the role of PM2. 5 on lung injury and cytokine levels in mice is currently …

Fine particulate matter and sulfur dioxide coexposures induce rat lung pathological injury and inflammatory responses via TLR4/p38/NF-κB pathway

R Li, L Zhao, J Tong, Y Yan… - International journal of …, 2017 - journals.sagepub.com
Fine particulate matter (PM2. 5) and sulfur dioxide (SO2) are 2 common air pollutants, but
their toxicological effects of coexposure are still not fully clear. In this study, SO2 exposure …

Lung injury, inflammation, and inflammatory stimuli in rats exposed to ozone

DKBSK Gupta - Journal of Toxicology and Environmental Health …, 2000 - Taylor & Francis
The effects of ozone (O3) on airway epithelia, inflammation, and expression of inflammatory
stimuli were investigated to delineate the mechanisms of inflam matory reactions relevant to …

Effects of ambient PM2.5 on pathological injury, inflammation, oxidative stress, metabolic enzyme activity, and expression of c-fos and c-jun in lungs of rats

R Li, X Kou, L Xie, F Cheng, H Geng - Environmental Science and …, 2015 - Springer
Abstract Fine particulate matter (PM 2.5) exposure is associated with morbidity and mortality
induced by respiratory diseases and increases the lung cancer risk. However, the …

Age, strain, and gender as factors for increased sensitivity of the mouse lung to inhaled ozone

EM Vancza, K Galdanes, A Gunnison… - Toxicological …, 2009 - academic.oup.com
Ozone (O3) is a respiratory irritant that leads to airway inflammation and pulmonary
dysfunction. Animal studies show that neonates are more sensitive to O3 inhalation than …

Effect of PM2. 5 environmental pollution on rat lung

B Yang, J Guo, C Xiao - Environmental Science and Pollution Research, 2018 - Springer
Particulate matter smaller than 2.5 μm (PM2. 5) is a continuing challenge to pulmonary
health. Here, we investigated the mechanisms involved in PM2. 5 exposure-induced acute …

PM2. 5‐induced lung inflammation in mice: Differences of inflammatory response in macrophages and type II alveolar cells

M He, T Ichinose, S Yoshida, T Ito, C He… - Journal of Applied …, 2017 - Wiley Online Library
Abstract Particulate matter 2.5 (< PM2. 5 μm) leads to chronic obstructive pulmonary
disease. In this study, biomarkers related to inflammation and oxidative stress in vitro and in …

Pulmonary inflammation and epithelial injury in response to acute ozone exposure in the rat

MV Pino, JR Levin, MY Stovall, DM Hyde - Toxicology and applied …, 1992 - Elsevier
To document the time course of the inflammatory response and epithelial injury in the lung
following and acute ozone exposure, rats were exposed to 1.0 ppm ozone for periods …

Cell injury and interstitial inflammation in rat lung after inhalation of ozone and urban particulates

IYR Adamson, R Vincent… - American journal of …, 1999 - atsjournals.org
Coexposure of the lung to urban dust along with ozone appears to potentiate ozone-induced
injury. This conclusion was derived from whole-lung studies involving tissue and lavaged …