With the discovery of several matrices which enable the ionization of DNA and RNA, matrix-
assisted laser desorption/ionization mass spectrometry (MALDI-MS) has become a powerful …

Since the invention of dideoxy DNA sequencing (1), the genomes of a number of organisms
have been either partially or completely sequenced, including two draft sequences of the …

Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry has become an
important analytical technique in nucleic acid research. MALDI is used for quality control of …

In the future, analysis of single nucleotide polymorphisms (SNPs) should become a powerful
tool for many genetic applications in areas such as association studies, pharmacogenetics …

The concept of matrix-assisted laser desorption/ionization mass spectrometry (MALDI MS)
was first reported in 1985. Since then, MALDI MS technologies have been evolving, and …

An approach to analyzing single-nucleotide polymorphisms (SNPs) found in the human
genome has been developed that couples a recently developed invasive cleavage assay for …

For various diagnostic analyses and the studies of functional genomics, the use of an
accurate and cost-effective analytic platform to analyze large numbers of samples is …

After completion of the human genome sequence the search for differences among
individual genomes has become the centre of focus for geneticists. Two different types of …

Conventional DNA sequencing is based on gel electrophoretic separation of the sequencing
products. Gel casting and electrophoresis are the time limiting steps, and the gel separation …

Mass spectrometry has emerged as a powerful analytical tool in various scientific
disciplines, and Matrix-Assisted Laser Desorption/Ionization Mass Spectrometry (MALDI …