Chiral secondary alcohols play an important role in pharmaceutical, agrochemical, and
chemical industries. In recent years, impressive steps forward have been achieved towards …

Enzymes are able to perform reactions under mild conditions, eg, pH and temperature, with
remarkable chemo-, regio-, and stereoselectivity. Because of this feature, the number of …

Over the past two years the application of ketoreductases in the commercial synthesis of
chiral alcohols has undergone a revolution. Biocatalysts are now often the preferred catalyst …

Enzymes are able to perform reactions under mild conditions, eg, pH and temperature, with
remarkable chemo-, regio-, and stereoselectivity. Due to this feature the number of …

Biocatalyzed asymmetric reduction of ketones is one of the most cost-effective and
environmentally friendly approaches for preparing chiral alcohols. However, few natural …

The use of engineered ketoreductases (KREDS), both as whole microbial cells and isolated
enzymes, in the highly enantiospecific reduction of prochiral ketones is reviewed. The …

Biocatalytic synthesis of enantiomerically pure compounds for pharmaceutical intermediates
is gaining momentum. This is the result of advances in genomics, screening and evolution …

Herein we review recent advances in the asymmetric reduction of ketones by biocatalysts.
Included are discussions on recent developments in methodologies to control …

The results of a reduction of a wide range of ketones using 31 commercially available
isolated ketoreductases (KREDs) are presented. All enzymes accepted a wide substrate …

The development of cell‐free and self‐sufficient biocatalytic systems represents an
emerging approach to address more complex synthetic schemes under nonphysiological …