Advances in liquid chromatography-mass spectrometry (LC-MS) instruments and analytical
strategies have brought about great progress in targeted metabolomics analysis. This …

Introduction We previously developed a tandem mass spectrometry-based label-free
targeted metabolomics analysis framework coupled to two distinct chromatographic …

Recent advances in analytical methodologies have made it possible to bring metabolomic
profiling into quantitative metabolomics that permits precise measurements of …

Modern analytical technologies afford comprehensive and quantitative investigation of a
multitude of different metabolites. Typical metabolomic experiments can therefore produce …

In recent years, metabolomics has emerged as a pivotal approach for the holistic analysis of
metabolites in biological systems. The rapid progress in analytical equipment, coupled to the …

We developed a new software program, MRMPROBS, for widely targeted metabolomics by
using the large-scale multiple reaction monitoring (MRM) mode. The strategy became …

Recent advances in mass spectrometry are enabling improved analysis of endogenous
metabolites. Here we discuss several issues relevant to developing liquid chromatography …

Metabolomics, the global study of small molecules in a particular system, has in the past few
years risen to become a primary-omics platform for the study of metabolic processes. With …

Typical mass spectrometry (MS) based untargeted metabolomics protocols are tedious as
well as time-and sample-consuming. In particular, they often rely on “full-scan-only” …

Targeted metabolomics has significant advantages for quantification but suffers from
reduced metabolite coverage. In this study, we developed a large-scale targeted …