Obesity represents one of the most serious global health issues with∼ 310 million people
presently affected. It develops because of a mismatch between energy intake and …

Obesity is a major public health problem not just in the United States but throughout the
world. The Worldwatch Institute, an Internet watchdog group, 22 now estimates that there are …

Evolution has molded metabolic thrift within humans, a genetic heritage that, when thrust
into our modern “obesogenic” environment, creates the current obesity crisis. Modern …

▪ Abstract Obesity is a health problem of epidemic proportions in the industrialized world.
The cloning and characterization of the genes for the five naturally occurring monogenic …

Obesity in laboratory rodents can be difficult to define, but increases in body fat content
above 'normal'can be achieved by surgical or chemical lesions in the ventromedial …

Obesity is defined medically as a state of increased body weight, more specifically adipose
tissue, of sufficient magnitude to produce adverse health consequences. There has been an …

Growing evidence implicates the brain in the regulation of both immediate fuel availability
(for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass) …

Complex central circuitry controls food intake and energy expenditure. Circulating factors
that modulate these pathways have appetite stimulation or satiety effects. These are …

Energy homeostasis involves a complex network of hypothalamic and extra-hypothalamic
neurons that transduce hormonal, nutrient and neuronal signals into responses that …

The World Health Organization has recognized obesity as a health problem of pandemic
proportions. Recent work led to major breakthroughs in the understanding of the molecular …