Objective: The first objective of this paper was to describe the pattern of remission, response
and recovery in patients with major depression who were randomised for treatment with …

Objective: Loss of response to a previously effective antidepressant is a common clinical
problem. Retrospective analyses have shown that the pattern of response during …

OBJECTIVE: Although the newer antidepressants are widely used, little is known about how
long it takes to see their full effect. The authors sought to determine how many weeks a …

Pooled data from multiple, double-blind clinical trials comparing fluoxetine with either
placebo, a tricyclic antidepressant (TCA) or both in patients with major depression were …

OBJECTIVE: The goals of this study were to determine the course of illness in a cohort of
depressed patients undergoing treatment for 6 months and whether there are clinically …

Background: In spite of impressive results in acute studies, the long-term treatment of major
depression remains problematic. To explore the return of depressive symptoms and their …

Background: Many patients treated for major depression require more than one
antidepressant trial to achieve or sustain response. However, the literature provides few …

One hundred and eight patients with major depression were treated with fluoxetine 20
mg/day for 3 weeks. Patients who failed to respond to this open-label treatment were …

Background: The goal was to examine predictors of relapse during continuation/
maintenance treatment of major depression that had remitted following 12 to 14 weeks of …

The safety and efficacy of nortriptyline and fluoxetine were compared in a double-blind,
randomized, multicenter 5-week trial involving 205 outpatients with acute major depression …