Ubiquitylation of receptor tyrosine kinases (RTKs) regulates their trafficking and lysosomal
degradation. The multidomain scaffolding protein intersectin 1 (ITSN1) is an important …

Ubiquitylation of receptor tyrosine kinases plays a critical role in regulating the trafficking
and lysosomal degradation of these important signaling molecules. We identified the …

The ubiquitin ligase Cbl mediates ubiquitination of activated receptor tyrosine kinases
(RTKs) and interacts with endocytic scaffold complexes, including CIN85/endophilins, to …

Receptor tyrosine kinases (RTKs) are critical for normal cell growth, differentiation, and
development, but they contribute to various pathological conditions when disrupted …

The Sprouty (Spry) proteins function as inhibitors of the Ras-ERK pathway downstream of
various receptor tyrosine kinases. In this study, we have identified Tesk1 (testicular protein …

Drosophila Sprouty (dSpry) was genetically identified as a novel antagonist of fibroblast
growth factor receptor (FGFR), epidermal growth factor receptor (EGFR) and Sevenless …

The Sprouty (Spry) proteins act as inhibitors of the Ras/ERK pathway downstream of
receptor tyrosine kinases. In this study, we report a novel interaction between protein kinase …

Sprouty, an inhibitor of receptor tyrosine kinase signaling, plays an important role in the
regulation of a wide variety of biological processes. Although it is established that the …

Sprouty (Spry) proteins are important regulators of receptor tyrosine kinase signaling in
development and disease. Alterations in cellular Spry content have been associated with …

Abstract SHPTP1 (PTP1C, HCP, SHP) is an SH2 domain-containing tyrosine phosphatase
expressed predominantly in hematopoietic cells. A frameshift mutation in the SHPTP1 gene …