Abstract β cells uniquely produce and secrete insulin under the control of several, integrated
signals, to maintain blood glucose concentrations within a narrow physiological interval. β …

Pancreatic beta cells uniquely synthetize, store, and release insulin. Specific molecular,
functional as well as ultrastructural traits characterize their insulin secretion properties and …

Diabetes mellitus (DM) is a group of metabolic disorders characterized by hyperglycemia. In
particular, type 2 diabetes (T2D) represents one of the main causes of death in the world …

Type 2 diabetes is characterized by peripheral insulin resistance and insufficient insulin
release from pancreatic islet β cells. However, the role and sequence of β cell dysfunction …

Type 2 diabetes is the most common form of diabetes in humans. It results from a
combination of factors that impair beta-cell function and tissue insulin sensitivity. However …

Abstract β-cell dysfunction is central to the onset and progression of type 2 diabetes.
Reduced islet number and/or diminished β-cell mass/volume in the pancreas of type 2 …

The goal for the treatment of patients with diabetes has today shifted from merely reducing
glucose concentrations to preventing the natural decline in β-cell function and delay the …

Abstract β-cell (beta-cell) impairment is central to the development and progression of
human diabetes, as a result of the combined effects of genetic and acquired factors …

Insulin release from pancreatic β-cells is required to maintain normal glucose homoeostasis
in man and many other animals. Defective insulin secretion underlies all forms of diabetes …

Cells in different tissues, including endocrine cells in the pancreas, live in complex
microenvironments that are rich in cellular and acellular components. Intricate interactions …