The inhibitory efficacy of two substituted coumarin derivatives on the activity of
neurodegenerative enzyme acetylcholinesterase (AChE) was assessed in aqueous buffer …

Alzheimer's disease (AD) is one of the most common forms of dementia and a significant
threat to the elderly populations, especially in the Western world. The rapid hydrolysis of the …

A series of novel hybrids has been synthesized by linking coumarin moiety through an
appropriate spacer to various substituted heterocyclic amines and evaluated as dual binding …

A large series of substituted coumarins linked through an appropriate spacer to 3‐hydroxy‐
N, N‐dimethylanilino or 3‐hydroxy‐N, N, N‐trialkylbenzaminium moieties were synthesized …

Coumarins of synthetic or natural origins are an important chemical class exerting diverse
pharmacological activities. In the present study, 26 novel O-alkylcoumarin derivatives were …

Twenty four 6-aminocoumarin based derivatives were synthesized according to two
schemes. All the compounds were screened for their acetylcholinesterase inhibitory activity …

Abstract A series of 3-substituted-7-aminoalcoxy-coumarin was designed and evaluated as
cholinesterase inhibitors and antioxidants. All compounds were effective in inhibiting AChE …

Alzheimer's disease is an irreversible and progressive brain disease that can cause
problems with memory and thinking skills. It is characterized by loss of cognitive ability and …

Inhibition of high cholinesterase levels including acetylcholinesterase (AChE) and
butyrylcholinesterase (BChE), is one of the most important strategies for the treatment of …

Acetylcholinesterase (AChE) is an important drug target for the treatment of Alzheimer's
disease. A novel series of coumarin–piperazine derivatives were synthesized and their …