Secreted frizzled related protein 3 (SFRP3) contains a cysteine-rich domain (CRD) that
shares homology with Frizzled CRD and regulates WNT signaling. Independent studies …

Secreted frizzled related protein 1 (SFRP1) is an antagonist of the transmembrane frizzled
receptor, a component of the Wnt signaling pathway, and has been suggested to be a …

Secreted frizzled-related proteins (SFRPs), containing five family members (SFRPs 1–5) are
putative extracellular Wnt inhibitors. Given their abilities to inhibit Wnt signalling, as well as …

The secreted frizzled-related protein 2 (SFRP2) plays a pivotal role in the Wnt pathway,
however, it functions as an agonist or an antagonist is still controversial. We profiled SFRP2 …

Background Secreted frizzled-related protein 1 (sFRP1), Wnt signalling regulator, can
positively or negatively regulate tumourigenesis and progression. We sought to determine …

Background Secreted frizzled-related protein 1 (SFRP1) is a member of the SFRPs family
that modulates the Wnt signal transduction pathway. Recent studies have showed down …

Disruption of the Wnt pathway is thought to be crucial in the development of human cancer.
Pathway inhibitory members of the secreted frizzled-related protein (SFRP) family were …

The secreted Frizzled-related protein 1 (SFRP1) is a Wingless-type (Wnt) antagonist that has
been associated with various malignancies, including renal cell carcinomas (RCC) …

Purpose Secreted frizzled related proteins (SFRPs) play important roles in tumor progress
through antagonizing Wnt signaling. However, SFRPs has not been systematically studied …

Secreted frizzled-related protein (SFRP) 2, an identified member of the SFRPs family of
molecules, is often methylated in human cancers and its down-regulation is closely related …