Bile acids profile, histopathological indices and genetic variants for non-alcoholic fatty liver disease progression

N Nimer, I Choucair, Z Wang, I Nemet, L Li, J Gukasyan… - Metabolism, 2021 - Elsevier
Objective Metabolomic studies suggest plasma levels of bile acids (BAs) are elevated
amongst subjects with non-alcoholic fatty liver disease (NAFLD) compared to healthy …

Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease

AD Lake, P Novak, P Shipkova, N Aranibar… - Toxicology and applied …, 2013 - Elsevier
Bile acids (BAs) have many physiological roles and exhibit both toxic and protective
influences within the liver. Alterations in the BA profile may be the result of disease induced …

Bile acids associate with specific gut microbiota, low‐level alcohol consumption and liver fibrosis in patients with non‐alcoholic fatty liver disease

LA Adams, Z Wang, C Liddle, PE Melton… - Liver …, 2020 - Wiley Online Library
Abstract Background Bile acids (BAs) are synthesized by the liver and modified by gut
bacteria, and may play an intermediary role between the gut microbiome and liver in …

Altered bile acid metabolome in patients with nonalcoholic steatohepatitis

BC Ferslew, G Xie, CK Johnston, M Su… - Digestive diseases and …, 2015 - Springer
Abstract Background and Aims The prevalence of nonalcoholic fatty liver disease (NAFLD)
and steatohepatitis (NASH) is increasing at an alarming rate. The role of bile acids in the …

The presence and severity of nonalcoholic steatohepatitis is associated with specific changes in circulating bile acids

P Puri, K Daita, A Joyce, F Mirshahi, PK Santhekadur… - Hepatology, 2018 - journals.lww.com
The histologic spectrum of nonalcoholic fatty liver disease (NAFLD) includes fatty liver
(NAFL) and steatohepatitis (NASH), which can progress to cirrhosis in up to 20% of NASH …

[HTML][HTML] Bile acids and dysbiosis in non-alcoholic fatty liver disease

M Mouzaki, AY Wang, R Bandsma, EM Comelli… - PloS one, 2016 - journals.plos.org
Background & Aims Non-alcoholic fatty liver disease (NAFLD) is characterized by dysbiosis.
The bidirectional effects between intestinal microbiota (IM) and bile acids (BA) suggest that …

Bile acid alterations are associated with insulin resistance, but not with NASH, in obese subjects

V Legry, S Francque, JT Haas… - The Journal of …, 2017 - academic.oup.com
Abstract Context Bile acids (BAs) are signaling molecules controlling energy homeostasis
that can be both toxic and protective for the liver. BA alterations have been reported in …

[HTML][HTML] NASH-related increases in plasma bile acid levels depend on insulin resistance

G Grzych, O Chávez-Talavera, A Descat, D Thuillier… - JHEP Reports, 2021 - Elsevier
Background & Aims Plasma bile acids (BAs) have been extensively studied as
pathophysiological actors in non-alcoholic steatohepatitis (NASH). However, results from …

Serum bile acid patterns are associated with the presence of NAFLD in twins, and dose‐dependent changes with increase in fibrosis stage in patients with biopsy …

C Caussy, C Hsu, S Singh, S Bassirian… - Alimentary …, 2019 - Wiley Online Library
Background The fasting‐state serum bile acid profile in nonalcoholic fatty liver disease
(NAFLD) has been reported to differ when nonalcoholic steatohepatitis is compared to …

Bile acid profiles are distinct among patients with different etiologies of chronic liver disease

C Sang, X Wang, K Zhou, T Sun, H Bian… - Journal of proteome …, 2021 - ACS Publications
A significant increase of bile acid (BA) levels has been recognized as a general metabolic
phenotype of diverse liver diseases. Monitoring of BA profiles has been proposed for …