siRNA versus miRNA as therapeutics for gene silencing
JKW Lam, MYT Chow, Y Zhang, SWS Leung - Molecular Therapy-Nucleic …, 2015 - cell.com
Discovered a little over two decades ago, small interfering RNAs (siRNAs) and microRNAs
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …
(miRNAs) are noncoding RNAs with important roles in gene regulation. They have recently …
Novel approaches in cancer treatment: preclinical and clinical development of small non-coding RNA therapeutics
R Cuciniello, S Filosa, S Crispi - Journal of Experimental & Clinical Cancer …, 2021 - Springer
Short or small interfering RNAs (siRNAs) and microRNA (miRNAs) are molecules similar in
size and function able to inhibit gene expression based on their complementarity with mRNA …
size and function able to inhibit gene expression based on their complementarity with mRNA …
[HTML][HTML] Effective tools for RNA-derived therapeutics: siRNA interference or miRNA mimicry
P Wang, Y Zhou, AM Richards - Theranostics, 2021 - ncbi.nlm.nih.gov
The approval of the first small interfering RNA (siRNA) drug Patisiran by FDA in 2018 marks
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
a new era of RNA interference (RNAi) therapeutics. MicroRNAs (miRNA), an important post …
Therapeutic miRNA and siRNA: moving from bench to clinic as next generation medicine
C Chakraborty, AR Sharma, G Sharma… - … Therapy-Nucleic Acids, 2017 - cell.com
In the past few years, therapeutic microRNA (miRNA) and small interfering RNA (siRNA) are
some of the most important biopharmaceuticals that are in commercial space as future …
some of the most important biopharmaceuticals that are in commercial space as future …
siRNA: Mechanism of action, challenges, and therapeutic approaches
W Alshaer, H Zureigat, A Al Karaki, A Al-Kadash… - European journal of …, 2021 - Elsevier
Owing to specific and compelling gene silencing, RNA interference (RNAi) is expected to
become an essential approach in treating a variety of infectious, hemato-oncological …
become an essential approach in treating a variety of infectious, hemato-oncological …
Therapeutic potential for microRNAs
CC Esau, BP Monia - Advanced drug delivery reviews, 2007 - Elsevier
MiRNAs are a conserved class of non-coding RNAs that negatively regulate gene
expression post-transcriptionally. Although their biological roles are largely unknown …
expression post-transcriptionally. Although their biological roles are largely unknown …
The race of 10 synthetic RNAi-based drugs to the pharmaceutical market
R Titze-de-Almeida, C David… - Pharmaceutical …, 2017 - Springer
Ten years after Fire and Melo's Nobel Prize for discovery of gene silencing by double-
stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes …
stranded RNA, a remarkable progress was achieved in RNA interference (RNAi). Changes …
siRNA, miRNA and HIV: promises and challenges
ML Yeung, Y Bennasser, SY Le, KT Jeang - Cell research, 2005 - nature.com
Small interfering RNA (siRNA) and microRNA (miRNA) are small RNAs of 18-25 nucleotides
(nt) in length that play important roles in regulating gene expression. They are incorporated …
(nt) in length that play important roles in regulating gene expression. They are incorporated …
Concepts in in vivo siRNA delivery for cancer therapy
CS Gondi, JS Rao - Journal of cellular physiology, 2009 - Wiley Online Library
In vivo gene silencing using RNAi plays an important role in target validation and is
advancing towards the development of RNAi‐based therapeutics. RNAs were thought to …
advancing towards the development of RNAi‐based therapeutics. RNAs were thought to …
Delivery strategies for siRNA-mediated gene silencing
IR Gilmore, SP Fox, AJ Hollins, S Akhtar - Current drug delivery, 2006 - ingentaconnect.com
RNA interference (RNAi) represents a promising new gene silencing technology for
functional genomics and a potential therapeutic strategy for a variety of genetic diseases …
functional genomics and a potential therapeutic strategy for a variety of genetic diseases …