Objective An increased sensitivity to angiotensin II (Ang II) has been observed in patients
with established hypertension. In the current study we tested whether young normotensive …

The responsiveness of plasma aldosterone to an angiotensin (Ang) II infusion was assessed
in normotensive young men, nine without and 13 with a family history of essential …

Background In hypertension, sodium sensitivity (SS) of blood pressure is associated with
renal hemodynamic abnormalities related to increased activity of the renal renin …

The aldosterone response to infused angiotensin II (Ang II) in patients receiving a low-salt
diet has been described as an important phenotype for genetic studies on human …

Normotensive young men (mean age 36 years) with positive (PFH)(n= 13) and negative (n=
29) family histories of hypertension were investigated in order to study systemic and renal …

Results Before chronic ACE inhibition, A2 increased mean arterial blood pressure (FH+,
8.7±0.8 mmHg; FH−, 8.9±0.9 mmHg), plasma immunoreactive A2 (FH+, 21±2 pg/ml; FH …

Background Primary hyperaldosteronism is a well-recognized cause of secondary
hypertension. It is unknown whether serum aldosterone levels within the physiologic range …

Low-renin essential hypertension (LREH) describes a widely recognized classification
validated by clinical features, including salt-sensitive blood pressure and diuretic …

Objectives An enhanced sensitivity to angiotensin II in the renal circulation has been
demonstrated in the pre-hypertensive phase both in the spontaneously hypertensive rat and …

Objective Recently, we reported evidence for genetic linkage between human essential
hypertension and the angiotensinogen gene (AGT) and an association with a common …