Prediction of essential proteins using topological properties in GO-pruned PPI network based on machine learning methods

W Kim - Tsinghua Science and Technology, 2012 - ieeexplore.ieee.org
The prediction of essential proteins, the minimal set required for a living cell to support
cellular life, is an important task to understand the cellular processes of an organism. Fast …

Detecting essential proteins based on network topology, gene expression data, and gene ontology information

W Zhang, J Xu, Y Li, X Zou - IEEE/ACM transactions on …, 2016 - ieeexplore.ieee.org
The identification of essential proteins in protein-protein interaction (PPI) networks is of great
significance for understanding cellular processes. With the increasing availability of large …

An iteration method for identifying yeast essential proteins from weighted PPI network based on topological and functional features of proteins

S Li, Z Chen, X He, Z Zhang, T Pei, Y Tan… - IEEE Access, 2020 - ieeexplore.ieee.org
Accumulating studies have indicated that essential proteins play critical roles in numerous
biological processes. With the rapid development of high-throughput technologies, a large …

Identifying essential proteins from active PPI networks constructed with dynamic gene expression

Q Xiao, J Wang, X Peng, F Wu, Y Pan - BMC genomics, 2015 - Springer
Essential proteins are vitally important for cellular survival and development, and identifying
essential proteins is very meaningful research work in the post-genome era. Rapid increase …

A novel essential protein identification method based on PPI networks and gene expression data

J Zhong, C Tang, W Peng, M Xie, Y Sun, Q Tang… - BMC …, 2021 - Springer
Background Some proposed methods for identifying essential proteins have better results by
using biological information. Gene expression data is generally used to identify essential …

A reliable neighbor-based method for identifying essential proteins by integrating gene expressions, orthology, and subcellular localization information

M Li, Z Niu, X Chen, P Zhong, F Wu… - Tsinghua Science and …, 2016 - ieeexplore.ieee.org
Essential proteins are those necessary for the survival or reproduction of species and
discovering such essential proteins is fundamental for understanding the minimal …

A new method for the discovery of essential proteins

X Zhang, J Xu, W Xiao - PloS one, 2013 - journals.plos.org
Background Experimental methods for the identification of essential proteins are always
costly, time-consuming, and laborious. It is a challenging task to find protein essentiality only …

Predicting essential proteins based on weighted degree centrality

X Tang, J Wang, J Zhong, Y Pan - IEEE/ACM Transactions on …, 2013 - ieeexplore.ieee.org
Essential proteins are vital for an organism's viability under a variety of conditions. There are
many experimental and computational methods developed to identify essential proteins …

United complex centrality for identification of essential proteins from PPI networks

M Li, Y Lu, Z Niu, FX Wu - IEEE/ACM transactions on …, 2015 - ieeexplore.ieee.org
Essential proteins are indispensable for the survival or reproduction of an organism.
Identification of essential proteins is not only necessary for the understanding of the minimal …

Predicting essential proteins by integrating orthology, gene expressions, and PPI networks

X Zhang, W Xiao, X Hu - PloS one, 2018 - journals.plos.org
Identifying essential proteins is very important for understanding the minimal requirements of
cellular life and finding human disease genes as well as potential drug targets. Experimental …