A critical question in natural product-based drug discovery is how to translate the product
into drug-like molecules with optimal pharmacological properties. The generation of natural …

Inspired by the natural product evodiamine, a novel antitumor indolopyrazinoquinazolinone
scaffold was designed by scaffold hopping. Structure–activity relationship studies led to the …

Evodiamine is a quinazolinocarboline alkaloid isolated from the fruits of traditional Chinese
herb Evodiae fructus. Previously, we identified N13-substituted evodiamine derivatives as …

It is a well-known phenomenon that natural products can serve as powerful drug leads to
generate new molecular entities with novel therapeutic utility. Evodiamine (Evo), a major …

Topoisomerase has been found extremely high level of expression in hepatocellular
carcinoma (HCC) and proven to promote the proliferation and survival of HCC. Cancer …

On the basis of the synergism of topoisomerase (Top) and histone deacetylase (HDAC)
inhibitors in antitumor therapy, a series of novel Top/HDAC dual inhibitors were designed …

Human topoisomerase I (TopoI) is recognized as a valuable target for the development of
effective antitumor agents. Structure-based virtual screening was applied to the discovery of …

Abstract Introduction Natural products (NPs) play a crucial role in the development of
therapeutic drugs. However, it is still highly challenging to identify the targets of NPs …

Evodiamine is a major alkaloid component found in the fruit of Evodia rutaecarpa. It shows
the anti-proliferative potential against a wide range of cancers by suppressing cell growth …

Improved, streamlined total syntheses of natural tubulysins such as V (Tb45) and U (Tb46)
and pretubulysin D (PTb-D43), and their application to the synthesis of designed tubulysin …