Background Topoisomerase II is critical for DNA replication, transcription and chromosome
segregation and is a well validated target of anti-neoplastic drugs including the …

Alkaloids, a category of natural products with ring structures and nitrogen atoms, include
most US Food and Drug Administration approved plant derived anti-cancer agents …

Exploring multi-targeting chemotherapeutants with advantages over single-targeting agents
and drug combinations is of great significance in drug discovery. Herein, we employed …

Tetrandrine is a dibenzyltetrahydroisoquinoline alkaloid, isolated from traditional Chinese
medicinal plant Stephania tetrandra, with anti-tumor activity. Our previous study identified …

The epipolythiodiketopiperazine (ETP) alkaloids are a highly complex class of natural
products with potent anticancer activity. Herein, we report the application of a flexible and …

A concise two one‐pot synthesis of WIN 64821, eurocristatine, 15, 15′‐bis‐epi‐
eurocristatine, ditryptophenaline, ditryptoleucine A, WIN 64745, cristatumin C, asperdimin …

Microtubule target agents (MTAs) are widely-used clinical anti-cancer drugs for decades, but
the acquired drug resistance severely restricted their application. Thioredoxin reductases …

Natural products represent a paramount source of novel drugs. Numerous plant-derived
natural products have demonstrated potent anti-tumor properties, thereby garnering …

The dominant paradigm in drug discovery is to design ligands with maximum selectivity to
act on individual drug targets. With the target-based approach, many new chemical entities …

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively
over the past four decades for their exceptionally potent anticancer activity, in addition to …