A concise two one‐pot synthesis of WIN 64821, eurocristatine, 15, 15′‐bis‐epi‐
eurocristatine, ditryptophenaline, ditryptoleucine A, WIN 64745, cristatumin C, asperdimin …

Microtubule target agents (MTAs) are widely-used clinical anti-cancer drugs for decades, but
the acquired drug resistance severely restricted their application. Thioredoxin reductases …

Evodiamine, a naturally occurring indole alkaloid, is one of the main bioactive ingredients of
Evodiae fructus. With respect to the pharmacological actions of evodiamine, more attention …

Evodiamine is a major alkaloid component found in the fruit of Evodia rutaecarpa. It shows
the anti-proliferative potential against a wide range of cancers by suppressing cell growth …

The bis-tetrahydroisoquinoline (bis-THIQ) natural products have been studied intensively
over the past four decades for their exceptionally potent anticancer activity, in addition to …

The dominant paradigm in drug discovery is to design ligands with maximum selectivity to
act on individual drug targets. With the target-based approach, many new chemical entities …

Natural products display impressive activities against a wide range of targets, including
viruses, microbes, and tumors. However, their clinical use is hampered frequently by their …

Traditional Chinese herbs are regarded as a new and promising source of potential anti-
cancer remedies and new chemotherapy adjuvants to enhance the efficacy of chemotherapy …

VEGF/VEGFR2 pathway is the crucial therapeutic target in the treatment of cancer. So that, a
new series of quinoxaline-2 (1H)-one derivatives were designed and synthesized. The …

Designing multitarget drugs remains a significant challenge in current antitumor drug
discovery. Because of the synergistic effect between topoisomerase and HDAC inhibitors …