Natural products (NPs) historically serve as a valuable and productive source of bioactive
compounds for drug development. The discovery of a range of alkaloids in the early 1800s …

The identification of new chemical entities is of paramount importance to the biomedical
sciences for the development of novel therapeutic agents, and natural products have …

Covering: up to 2020 Natural products have a long history in drug discovery, with their
inherent biological activity often tailored by medicinal chemists to arrive at the final drug …

Cancer still represents a major global health problem. All currently available anticancer
agents have disadvantages like resistance or side effects. Therefore, introduction of novel …

The quinoxaline scaffold is a promising platform for the discovery of active chemotherapeutic
agents. Three series of quinoxaline derivatives were synthesized and biologically evaluated …

Background: Cancer has been considered to be a global health concern due to the impact of
disease on the quality of life. The continual increase of cancer cases as well as the …

The family of anthraquinone-fused enediyne antitumor antibiotics was established by the
discovery of dynemicin A and deoxy-dynemicin A. It was then expanded, first by the isolation …

In search for new and safer anti-cancer agents, a structurally guided pharmacophore
hybridization strategy of two privileged scaffolds, namely diaryl pyrazolines and …

A streamlined total synthesis of N 14-desacetoxytubulysin H (Tb1) based on a C–H
activation strategy and a short total synthesis of pretubulysin D (PTb-D43) are described …

Evodiamine is one of the main components isolated from Evodia rutaecarpa, and it has been
reported to exert inhibitory effects on cancers by anti-proliferative and apoptosis-inducing …