[HTML][HTML] Synthetic and naturally occurring heterocyclic anticancer compounds with multiple biological targets
Cancer is a complex group of diseases initiated by abnormal cell division with the potential
of spreading to other parts of the body. The advancement in the discoveries of omics and bio …
of spreading to other parts of the body. The advancement in the discoveries of omics and bio …
Discovery of novel quinoline–chalcone derivatives as potent antitumor agents with microtubule polymerization inhibitory activity
A series of novel quinoline–chalcone derivatives were designed, synthesized, and
evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most …
evaluated for their antiproliferative activity. Among them, compound 24d exhibited the most …
11H-Isoquino [4, 3-c] cinnolin-12-ones: novel anticancer agents with potent topoisomerase I-targeting activity and cytotoxicity
Recent studies have identified 2, 3-dimethoxy-8, 9-methylenedioxy-11-[(2-dimethylamino)
ethyl]-11H-isoquino [4, 3-c] cinnolin-12-one (1a) as a novel topoisomerase I-targeting agent …
ethyl]-11H-isoquino [4, 3-c] cinnolin-12-one (1a) as a novel topoisomerase I-targeting agent …
Network-analysis-guided synthesis of weisaconitine D and liljestrandinine
CJ Marth, GM Gallego, JC Lee, TP Lebold, S Kulyk… - Nature, 2015 - nature.com
General strategies for the chemical synthesis of organic compounds, especially of
architecturally complex natural products, are not easily identified. Here we present a method …
architecturally complex natural products, are not easily identified. Here we present a method …
Synthesis and in vitro antitumor activity of novel naphthyridinone derivatives
XD Jia, S Wang, MH Wang, ML Liu, GM Xia… - Chinese Chemical …, 2017 - Elsevier
A series of naphthyridinone derivatives based on 1a (a precursor of Voreloxin) were
designed and synthesized. Seven compounds having> 70% inhibition against HL60 at 30 …
designed and synthesized. Seven compounds having> 70% inhibition against HL60 at 30 …