B lymphocytes are critical for effective immunity; they produce antibodies and cytokines,
present antigens to T lymphocytes and regulate immune responses. However, because of …

[Frontiers in Bioscience 4852-4861, May 1, 2008] 4852 B lymphocytes — chief players and
therapeutic targets in autoimmune dis Page 1 [Frontiers in Bioscience 4852-4861, May 1, 2008] …

Following investigations of the pathogenic role of autoantibodies in rheumatic diseases,
preclinical and clinical studies suggest a more central role of B cells in the maintenance of …

Abnormal B lymphocytes influence the pathogenesis of many autoimmune diseases, in
addition to serving as the origin of pathogenic autoantibodies. Although aberrant B cell …

B-lymphocytes have traditionally been thought to contribute to immunity and autoimmune
disease through terminal differentiation into plasma cells that secrete antibody. However …

The immune receptors of lymphocytes are able to sense the nature of bound ligands.
Through coupled signaling pathways the generated signals are appropriately delivered to …

In this review, we describe the non‐antibody‐mediated functions of B cells within the
immune system. In addition to antibody production, B cells also present antigen to T cells …

The interest for B cells has recently been revived. They normally play a role in the
development, the regulation, as well as the activation of lymphoid architecture: they regulate …

Our early concepts of the normal role of B cells in immunity focused on their ability to
produce antibodies (Ab) and in the case of autoimmune diseases autoAbs, some of which …

B-lymphocytes are integral to host defense against microbial pathogens and are associated
with many autoimmune diseases. The B-cell receptor implements B-cell self-tolerance …