Direct and indirect air particle cytotoxicity in human alveolar epithelial cells

NS Orona, F Astort, GA Maglione, PHN Saldiva… - Toxicology in Vitro, 2014 - Elsevier
Air particulate matter has been associated with adverse impact on the respiratory system
leading to cytotoxic and proinflammatory effects. The biological mechanisms behind these …

Aggregates of ultrafine particles modulate lipid peroxidation and bacterial killing by alveolar macrophages

M Lundborg, R Bouhafs, P Gerde, P Ewing… - Environmental …, 2007 - Elsevier
We hypothesized that aggregates of ultrafine carbon and washed diesel particles impair the
ability of alveolar macrophages (AM) to kill bacteria and enhance the AM lipid peroxidation …

Chemical composition of ambient particulate matter and redox activity

HA Jeng - Environmental monitoring and assessment, 2010 - Springer
Exposure to ambient particulate matter (PM) has been associated with a number of adverse
health effects. Increasing studies have suggested that such adverse health effects may …

Acetaldehyde (CH3CHO) production in rodent lung after exposure to metal-rich particles

MC Madden, MJ Thomas, AJ Ghio - Free Radical Biology and Medicine, 1999 - Elsevier
Epidemiological reports demonstrate an association between increased human morbidity
and mortality with exposure to air pollution particulate matter (PM). Metal-catalyzed oxidative …

Systemic microvascular dysfunction and inflammation after pulmonary particulate matter exposure

TR Nurkiewicz, DW Porter, M Barger… - Environmental …, 2006 - ehp.niehs.nih.gov
The epidemiologic association between pulmonary exposure to ambient particulate matter
(PM) and cardiovascular dysfunction is well known, but the systemic mechanisms that drive …

A macrophage-based method for the assessment of the reactive oxygen species (ROS) activity of atmospheric particulate matter (PM) and application to routine (daily …

AP Landreman, MM Shafer, JC Hemming… - Aerosol Science and …, 2008 - Taylor & Francis
Both short-and long-term exposure to particulate matter (PM) air pollution have been
demonstrated to cause increases in cardiovascular disease, cancer, and respiratory …

Regulation of cytokine production in human alveolar macrophages and airway epithelial cells in response to ambient air pollution particles: further mechanistic studies

S Becker, S Mundandhara, RB Devlin… - Toxicology and applied …, 2005 - Elsevier
In order to better understand how ambient air particulate matter (PM) affect lung health, the
two main airway cell types likely to interact with inhaled particles, alveolar macrophages …

Airborne particulate matter and human health: toxicological assessment and importance of size and composition of particles for oxidative damage and carcinogenic …

A Valavanidis, K Fiotakis… - Journal of Environmental …, 2008 - Taylor & Francis
Air pollution has been considered a hazard to human health. In the past decades, many
studies highlighted the role of ambient airborne particulate matter (PM) as an important …

Soluble components of Utah Valley particulate pollution alter alveolar macrophage function in vivo and in vitro

JM Soukup, AJ Ghio, S Becker - Inhalation Toxicology, 2000 - Taylor & Francis
Water-soluble extracts of Utah Valley dust (UVD) have been found to cause inflammatory
injury of the lung in both humans and rodents. The degree of lung damage found correlated …

Source-dependent variation in hydroxyl radical production by airborne particulate matter

M Alaghmand, NV Blough - Environmental science & technology, 2007 - ACS Publications
Epidemiological studies suggest exposure to airborne particles is responsible for a wide
range of adverse health effects, potentially arising from particle-induced oxidative stress. A …