'Heads and tails' of intermediate filament phosphorylation: multiple sites and functional insights

MB Omary, NO Ku, GZ Tao, DM Toivola… - Trends in biochemical …, 2006 - cell.com
Intermediate filaments (IFs) are major components of the mammalian cytoskeleton. They are
among the most abundant cellular phosphoproteins; their phosphorylation typically involves …

Implications of intermediate filament protein phosphorylation

NO Ku, J Liao, CF Chou, MB Omary - Cancer and Metastasis Reviews, 1996 - Springer
Intermediate filament (IF) proteins, a large family of tissue specific proteins, undergo several
posttranslational modifications, with phosphorylation being the most studied modification. IF …

Intermediate filament assembly: dynamics to disease

LM Godsel, RP Hobbs, KJ Green - Trends in cell biology, 2008 - cell.com
Intermediate filament (IF) proteins belong to a large and diverse gene family with broad
representation in vertebrate tissues. Although considered the 'toughest'cytoskeletal fibers …

Cellular integrity plus: organelle-related and protein-targeting functions of intermediate filaments

DM Toivola, GZ Tao, A Habtezion, J Liao… - Trends in cell biology, 2005 - cell.com
Intermediate filament proteins (IFs) maintain cell and tissue integrity, based on evidence of
their polymerization and mechanical properties, abundance and disease-associated …

Intermediate filament scaffolds fulfill mechanical, organizational, and signaling functions in the cytoplasm

S Kim, PA Coulombe - Genes & development, 2007 - genesdev.cshlp.org
Intermediate filaments (IFs) are cytoskeletal polymers whose protein constituents are
encoded by a large family of differentially expressed genes. Owing in part to their properties …

Post-translational modifications of intermediate filament proteins: mechanisms and functions

NT Snider, MB Omary - Nature reviews Molecular cell biology, 2014 - nature.com
Intermediate filaments (IFs) are cytoskeletal and nucleoskeletal structures that provide
mechanical and stress-coping resilience to cells, contribute to subcellular and tissue-specific …

Beyond structure: do intermediate filaments modulate cell signalling?

JM Paramio, JL Jorcano - Bioessays, 2002 - Wiley Online Library
Intermediate filament (IF) proteins form the largest family of cytoskeletal proteins in
mammalian cells. The function of these proteins has long been thought to be only structural …

Intermediate filaments as effectors of differentiation

CJ Redmond, PA Coulombe - Current opinion in cell biology, 2021 - Elsevier
After the initial discovery of intermediate filament (IF)–forming proteins in 1968, a decade
would elapse before they were revealed to comprise a diverse group of proteins which …

Cytoplasmic intermediate filaments in cell biology

S Etienne-Manneville - Annual review of cell and …, 2018 - annualreviews.org
Intermediate filaments (IFs) are one of the three major elements of the cytoskeleton. Their
stability, intrinsic mechanical properties, and cell type–specific expression patterns …

Dynamic property of intermediate filaments: regulation by phosphorylation

M Inagaki, Y Matsuoka, K Tsujimura, S Ando… - …, 1996 - Wiley Online Library
Site‐specific phosphorylation of intermediate filament (IF) proteins on serine and threonine
residues leads to alteration of the filament structure, in vitro and in vivo. Protein kinases …