Type 2 Diabetes Mellitus (T2DM), one of the most common metabolic disorders, is caused
by a combination of two primary factors: defective insulin secretion by pancreatic β-cells and …

Type 2 diabetes mellitus (T2DM) is characterized by defects in insulin action and insulin
secretion. Although insulin resistance manifests early during the prediabetic state, a failing β …

A generally accepted view posits that insulin resistant condition in type 2 diabetes is caused
by defects at one or several levels of the insulin-signaling cascade in skeletal muscles …

Insulin, a hormone produced by pancreatic β-cells, has a primary function of maintaining
glucose homeostasis. Deficiencies in β-cell insulin secretion result in the development of …

Insulin resistance is one of the earliest defects in the pathogenesis of type 2 diabetes. Over
the past 50 years, elucidation of the insulin signalling network has provided important …

Type 1 diabetes mellitus (T1DM) is a disease where destruction of the insulin producing
pancreatic beta-cells leads to increased blood sugar levels. Both genetic and environmental …

The past two decades have seen an explosive increase in the number of people diagnosed
with diabetes mellitus worldwide, particularly type 2 diabetes (T2D), which is found …

The 1921 discovery of insulin was a Big Bang from which a vast and expanding universe of
research into insulin action and resistance has issued. In the intervening century, some …

A complex metabolic condition referred to as Type 2 diabetes mellitus (T2DM) is
characterized by insulin resistance (IR) and decreased insulin production. Obesity …

Nearly unlimited supplies of energy-dense foods and technologies that encourage
sedentary behaviour have introduced a new threat to the survival of our species: obesity and …