Background Sepsis is common, deadly, and heterogenous. Prior analyses of patients with
sepsis and septic shock in New York State showed a risk-adjusted association between …

Introduction Intravenous fluid administration is an essential component of sepsis
management, but a positive fluid balance has been associated with worse prognosis. We …

Introduction In patients with severe sepsis and septic shock as cause of Intensive Care Unit
(ICU) admission, we analyze the impact on mortality of adequate antimicrobial therapy …

Introduction Sepsis is a leading cause of admission to non-cardiological intensive care units
(ICUs) and the second leading cause of death among ICU patients. We present the first …

Introduction Although early institution of adequate antimicrobial therapy is lifesaving in
sepsis patients, optimal antimicrobial strategy has not been established. Moreover, the …

Introduction Due to the increasing burden on hospital systems, most elderly patients with
non-surgical sepsis are admitted to general internal medicine departments. Disease-severity …

Background Clinical and biologic phenotypes of sepsis are proposed in human studies, yet
it is unknown whether prognostic or drug response phenotypes are present in animal …

Introduction Recent models capturing the pathophysiology of sepsis and ex-vivo data from
patients are speculating about immunosuppression in the so-called late phase of sepsis …

Introduction New challenges have arisen for the management of critically ill HIV/AIDS
patients. Severe sepsis has emerged as a common cause of intensive care unit (ICU) …

Introduction We evaluated the accuracy of hospital discharge diagnoses in the identification
of community-acquired sepsis and severe sepsis. Methods We reviewed 379 serious …